在单重态氧供体KHSO5存在的情况下，博来霉素-三价铁复合物产生的DNA断裂。
DNA breaks generated by the bleomycin-iron III complex in the presence of KHSO5, a single oxygen donor.
作者信息
Pratviel G, Bernadou J, Meunier B
出版信息
Biochem Biophys Res Commun. 1986 May 14;136(3):1013-20. doi: 10.1016/0006-291x(86)90434-1.
PMID:2424435
Abstract
KHSO5, a water soluble single oxygen donor, is shown to be capable of activating bleomycin-FeIII complex for DNA cleavage. DNA breaks mediated by bleomycin-FeIII in the presence of H2O2 or KHSO5 are compared and the P450-like activation of metallobleomycins is discussed.
摘要
KHSO5是一种水溶性单氧供体，已证明它能够激活博来霉素-FeIII复合物以进行DNA切割。对在过氧化氢或KHSO5存在下由博来霉素-FeIII介导的DNA断裂进行了比较，并讨论了金属博来霉素的类细胞色素P450激活作用。
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