Pratviel G, Bernadou J, Meunier B
Laboratoire de Chimie de Coordination du CNRS, Toulouse, France.
Biochem Pharmacol. 1989 Jan 1;38(1):133-40. doi: 10.1016/0006-2952(89)90159-7.
The activity of bleomycin is generally attributed to its ability to cleave DNA through the mediation of transition metal salts, molecular oxygen and electrons. Despite the fact that DNA break products are known with great details, the exact nature of the so-called "activated bleomycin", responsible for the activation of C--H bonds of the deoxyriboses, is still a matter of debate. In the present article, we report evidence that high-valent iron-oxo species might be generated by potassium hydrogen persulfate, KHSO5 (a single oxygen atom donor) and are involved in metallobleomycin-mediated DNA breaks.
博来霉素的活性通常归因于其通过过渡金属盐、分子氧和电子的介导来切割DNA的能力。尽管DNA断裂产物已为人熟知，但负责激活脱氧核糖C-H键的所谓“活化博来霉素”的确切性质仍存在争议。在本文中，我们报告了过硫酸氢钾（KHSO5，一种单氧原子供体）可能生成高价铁氧物种并参与金属博来霉素介导的DNA断裂的证据。
