内灌注蜗牛神经元中的持续性内向钙电流。
Persistent calcium inward current in internally perfused snail neuron.
作者信息
Oyama Y, Akaike N, Nishi K
出版信息
Cell Mol Neurobiol. 1986 Mar;6(1):71-85. doi: 10.1007/BF00742977.
The inactivation process of the calcium current (ICa) was investigated in a molluscan neuron which was perfused intracellularly and voltage-clamped using a suction pipette technique. The decay phase of the ICa contained a very slowly inactivated component (persistent inward current; PIC). The decay time constant of this component was over 10 sec. An increase in the amplitude of the ICa or the intracellular Ca2+ concentration caused a decrease in the decay time constant of the PIC. Replacing Ba2+ with extracellular Ca2+ increased the decay time constant of the PIC. The differences in the amplitude and the decay kinetics between the ICa and the IBa resulted from changes in the amplitude and the decay time constant of the PIC. These observations support the conclusion that the inactivation of the PIC is calcium dependent [Chad, J., Eckert, R., and Ewald, D. (1984). J. Physiol. (Lond.) 347:279-300].
利用吸移管技术，在进行细胞内灌注并电压钳制的软体动物神经元中，研究了钙电流（ICa）的失活过程。ICa的衰减相包含一个非常缓慢失活的成分（持续性内向电流；PIC）。该成分的衰减时间常数超过10秒。ICa幅度或细胞内Ca2+浓度的增加导致PIC的衰减时间常数减小。用细胞外Ca2+替代Ba2+会增加PIC的衰减时间常数。ICa和IBa在幅度和衰减动力学上的差异源于PIC幅度和衰减时间常数的变化。这些观察结果支持以下结论：PIC的失活依赖于钙[查德，J.，埃克特，R.，和埃瓦尔德，D.（1984年）。《生理学杂志》（伦敦）347:279 - 300]。
Zotero 插件