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Experimental reduction of B-cell mass: implications for the pathogenesis of diabetes.

作者信息

Weir G C, Leahy J L, Bonner-Weir S

出版信息

Diabetes Metab Rev. 1986;2(1-2):125-61. doi: 10.1002/dmr.5610020108.

DOI:10.1002/dmr.5610020108
PMID:2424696
Abstract
摘要

相似文献

1
Experimental reduction of B-cell mass: implications for the pathogenesis of diabetes.实验性减少B细胞数量：对糖尿病发病机制的影响
Diabetes Metab Rev. 1986;2(1-2):125-61. doi: 10.1002/dmr.5610020108.
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Purified islet cells in diabetes research.
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Abnormal glucose regulation of insulin secretion in models of reduced B-cell mass.胰岛β细胞数量减少模型中胰岛素分泌的葡萄糖调节异常。
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Islet-cell abnormalities in non-insulin-dependent diabetes mellitus.非胰岛素依赖型糖尿病中的胰岛细胞异常。
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Defective insulin and glucagon secretion in isolated perfused pancreata of diabetic WBN/Kob rats.糖尿病WBN/Kob大鼠分离灌注胰腺中胰岛素和胰高血糖素分泌缺陷
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Beta-cell dysfunction in hyperglycaemic rat models: recovery of glucose-induced insulin secretion with lowering of the ambient glucose level.高血糖大鼠模型中的β细胞功能障碍：随着周围葡萄糖水平降低，葡萄糖诱导的胰岛素分泌得以恢复。
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7
[Animal models of non-insulin-dependent diabetes induced in the rat by experimental reduction of B cell mass].[通过实验性减少大鼠胰岛B细胞数量诱导非胰岛素依赖型糖尿病的动物模型]
Journ Annu Diabetol Hotel Dieu. 1988:33-46.
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Effects of cryopreservation on in vitro and in vivo long-term function of human islets.冷冻保存对人胰岛体外和体内长期功能的影响。
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Glucagon, insulin and somatostatin secretion in response to sympathetic neural activation in streptozotocin-induced diabetic rats. A study with the isolated perfused rat pancreas in vitro.链脲佐菌素诱导的糖尿病大鼠中胰高血糖素、胰岛素和生长抑素对交感神经激活的分泌反应。一项关于体外分离灌注大鼠胰腺的研究。
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Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats.艾塞那肽-4可刺激β细胞复制和新生，从而增加糖尿病大鼠的β细胞量并改善其糖耐量。
Diabetes. 1999 Dec;48(12):2270-6. doi: 10.2337/diabetes.48.12.2270.

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β-cell mass in people with type 2 diabetes.2型糖尿病患者的β细胞量
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Experimental model proposed to deduce pharmacological evidence of the beta-cell neogenesis activity of Argyrolobium roseum vis-a-vis an evaluation of its hypoglycemic activity.
提出的实验模型，旨在推断玫瑰银合欢的β细胞新生活性的药理学证据及其降血糖活性评估。
Int J Appl Basic Med Res. 2011 Jul;1(2):97-103. doi: 10.4103/2229-516X.91153.
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A rice bran oil diet improves lipid abnormalities and suppress hyperinsulinemic responses in rats with streptozotocin/nicotinamide-induced type 2 diabetes.米糠油饮食可改善链脲佐菌素/烟酰胺诱导的 2 型糖尿病大鼠的脂质异常和抑制高胰岛素血症反应。
J Clin Biochem Nutr. 2009 Jul;45(1):29-36. doi: 10.3164/jcbn.08-257. Epub 2009 Jun 30.
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Reduction of beta cell mass: partial insulin secretory compensation from the residual beta cell population in the nicotinamide-streptozotocin Göttingen minipig after oral glucose in vivo and in the perfused pancreas.β细胞量的减少：烟酰胺-链脲佐菌素处理的哥廷根小型猪口服葡萄糖后，体内及灌注胰腺中残余β细胞群的部分胰岛素分泌代偿。
Diabetologia. 2004 Nov;47(11):1873-8. doi: 10.1007/s00125-004-1546-9. Epub 2004 Nov 24.
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Decreased beta-cell mass in diabetes: significance, mechanisms and therapeutic implications.糖尿病中β细胞质量减少：意义、机制及治疗意义
Diabetologia. 2004 Mar;47(3):581-589. doi: 10.1007/s00125-004-1336-4. Epub 2004 Feb 7.
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Loss of beta-cell mass leads to a reduction of pulse mass with normal periodicity, regularity and entrainment of pulsatile insulin secretion in Göttingen minipigs.在哥廷根小型猪中，β细胞质量的丧失导致脉冲质量降低，同时脉冲式胰岛素分泌具有正常的周期性、规律性和同步性。
Diabetologia. 2003 Feb;46(2):195-202. doi: 10.1007/s00125-002-1011-6. Epub 2003 Jan 11.
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Beta-cell growth in adolescent and adult rats treated with streptozotocin during the neonatal period.新生期接受链脲佐菌素治疗的青春期和成年大鼠的β细胞生长
Diabetologia. 1996 May;39(5):548-57. doi: 10.1007/BF00403301.
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Abnormal insulin secretion and glucose metabolism in pancreatic islets from the spontaneously diabetic GK rat.自发性糖尿病GK大鼠胰岛中胰岛素分泌和葡萄糖代谢异常。
Diabetologia. 1993 Jan;36(1):3-8. doi: 10.1007/BF00399086.
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Irreversible loss of normal beta-cell regulation by glucose in neonatally streptozotocin diabetic rats.新生期链脲佐菌素诱导糖尿病大鼠中葡萄糖对正常β细胞调节的不可逆丧失。
Diabetologia. 1994 Apr;37(4):351-7. doi: 10.1007/BF00408470.