Evangelisches Krankenhaus Kalk, University of Cologne, Cologne, Germany.
Dig Dis. 2013;31(3-4):385-7. doi: 10.1159/000354706. Epub 2013 Nov 14.
Ample research has described multiple biological activities of probiotics in animals and in humans. Probiotics interfere with local and systemic immune reactions and thus exert an influence on the barrier function of the intestinal mucosa. Therefore, attempting inflammatory bowel disease treatment with probiotics seems reasonable. In fact, a growing number of trials have studied the therapeutic effects in ulcerative colitis and Crohn's disease. Promising results have been found and in some, indications such as maintenance of remission of ulcerative colitis and pouchitis guidelines recommend therapy with probiotics already today. However, many open questions still remain and the urgent need for high-quality trials requires much more research in the future.
大量研究已经描述了益生菌在动物和人类中的多种生物学活性。益生菌会干扰局部和全身免疫反应，从而对肠道黏膜的屏障功能产生影响。因此，尝试使用益生菌来治疗炎症性肠病似乎是合理的。事实上，越来越多的试验已经研究了益生菌在溃疡性结肠炎和克罗恩病中的治疗效果。已经发现了有希望的结果，在某些情况下，例如溃疡性结肠炎和袋炎的缓解维持，指南建议今天就开始使用益生菌进行治疗。然而，仍有许多悬而未决的问题，迫切需要高质量的试验，这需要未来进行更多的研究。
