Plachý J, Spaténková Z, Ríhová B, Boubelík M
Folia Biol (Praha). 1986;32(2):116-27.
Natural agglutinating antibodies in normal sera from A and B10 mice react exclusively with antigenic determinants of the polymorphic Ea-A blood group system (a non-histocompatibility system) of the chicken. Agglutinating activity of these "natural" antibodies, which was demonstrated in the IgM fraction of the serum, did not correlate with the cytotoxic activity against chicken cells in A mice compared to B10 mice. "Natural" agglutinating antibodies against antigens A13 and A14 present in chickens of congenic lines were demonstrated in NMS from A mice. On the other hand, B10 mice showed no antibody reactivity against A13 antigen. The antibody reactions against antigen A13 could be induced in B10 mice by immunization with the respective erythrocytes. In this case, the antibody activity was concentrated in the IgG fraction of the serum. After immunization of B10 mice, agglutinating antibodies against antigenic determinants of the Ea-B (MHC) system appeared, which were not detected in NMS.
来自A和B10小鼠的正常血清中的天然凝集抗体仅与鸡的多态性Ea - A血型系统（非组织相容性系统）的抗原决定簇发生反应。这些“天然”抗体的凝集活性在血清的IgM部分得到证实，与A小鼠相比，B10小鼠中其凝集活性与针对鸡细胞的细胞毒性活性无关。在A小鼠的正常小鼠血清（NMS）中证实了针对同基因系鸡中存在的抗原A13和A14的“天然”凝集抗体。另一方面，B10小鼠对A13抗原没有抗体反应性。通过用相应的红细胞免疫可在B10小鼠中诱导针对抗原A13的抗体反应。在这种情况下，抗体活性集中在血清的IgG部分。用B10小鼠免疫后，出现了针对Ea - B（MHC）系统抗原决定簇的凝集抗体，而在正常小鼠血清中未检测到。
