Lee Kyung Real, Lee Eo Gin, Lee Hee Jung, Yoon Moon Soo
Korea Dermatology Research Institute (KDRI), Seongnam-si, Gyeonggi-do, Korea.
Lasers Surg Med. 2013 Dec;45(10):639-47. doi: 10.1002/lsm.22200. Epub 2013 Nov 19.
A minimally invasive fractional radiofrequency microneedle (FRM) device has been used in skin rejuvenation and acne scars, and a recent pilot study demonstrated the positive therapeutic effect on acne. We evaluated the efficacy of FRM device for acne vulgaris in Asians and conducted objective measurement to assess its effect on sebum production.
Twenty Korean patients with acne vulgaris received a single full-face FRM treatment. Outcome assessments included standardized photography, physician's global assessment, patient's satisfaction scores, acne lesion count, and objective measurements of casual sebum level (CSL) and sebum excretion rate (SER). They were evaluated at baseline and 2, 4, 8 weeks after the treatment.
After a single FRM treatment, the CSL and the SER showed 30-60% and 70-80% reduction, respectively, at week 2 (P < 0.01), and remained below the baseline level until week 8. Physician's global improvement scores for acne severity and acne lesion count also revealed clinical improvement with maximum efficacy at week 2, but returned to the baseline in most patients by week 8. Patients' satisfaction scores (0-4) were above 2 on average, and adverse effects were minimal.
This prospective study demonstrated the sebosuppressive effect from a single FRM treatment, but its therapeutic efficacy in acne requires further evaluation.
一种微创分次射频微针（FRM）设备已用于皮肤年轻化和痤疮瘢痕治疗，最近一项初步研究证明其对痤疮有积极治疗效果。我们评估了FRM设备对亚洲寻常痤疮患者的疗效，并进行客观测量以评估其对皮脂分泌的影响。
20例韩国寻常痤疮患者接受了一次全脸FRM治疗。结果评估包括标准化摄影、医生整体评估、患者满意度评分、痤疮皮损计数，以及对随意皮脂水平（CSL）和皮脂排泄率（SER）的客观测量。在治疗前及治疗后2周、4周、8周进行评估。
单次FRM治疗后，第2周时CSL和SER分别降低了30% - 60%和70% - 80%（P < 0.01），并在第8周前一直低于基线水平。医生对痤疮严重程度和痤疮皮损计数的整体改善评分也显示在第2周时临床改善最明显，但大多数患者在第8周时恢复到基线水平。患者满意度评分（0 - 4分）平均高于2分，且不良反应轻微。
这项前瞻性研究证明了单次FRM治疗具有抑制皮脂分泌的作用，但其对痤疮的治疗效果仍需进一步评估。
