Seo Kyu Young, Yoon Moon Soo, Kim Dong Hyun, Lee Hee Jung
Department of Dermatology, CHA Bundang Medical Center, CHA University, Republic of Korea.
Lasers Surg Med. 2012 Oct;44(8):631-6. doi: 10.1002/lsm.22071. Epub 2012 Aug 30.
For skin rejuvenation, microneedle fractional radiofrequency (RF) is a recently developed minimally invasive method for delivering RF energy directly into the skin using microneedle.
We evaluated efficacy and safety of microneedle fractional RF for skin rejuvenation in Asian skin and also conducted immunohistochemical analysis before and after treatment.
Twenty-five females (mean age 54.2, Fitzpatrick skin phototypes III-IV) received three consecutive fractional RF treatment at 4-week intervals. Outcome assessments included standardized photography, physician's global assessment, patient's satisfaction scores, objective biophysical measurements, and histologic analysis including immunohistochemical staining.
All patients showed clinical improvement on physician's global assessment and patient's satisfaction scores. Among objective biophysical measurements, improvement in hydration and skin roughness was noticed. Histologic examination revealed marked increase in dermal thickness, dermal collagen content and dermal fibrillin content. Side effects were minimal.
The limitations are the small number of patients and lack of long-term follow-up.
Microneedle fractional RF is a safe and effective skin rejuvenation method in Asians.
对于皮肤年轻化，微针分数射频是一种最近开发的微创方法，可使用微针将射频能量直接输送到皮肤中。
我们评估了微针分数射频用于亚洲人皮肤年轻化的疗效和安全性，并在治疗前后进行了免疫组织化学分析。
25名女性（平均年龄54.2岁，Fitzpatrick皮肤光类型III-IV）每隔4周接受连续三次分数射频治疗。结果评估包括标准化摄影、医生整体评估、患者满意度评分、客观生物物理测量以及包括免疫组织化学染色在内的组织学分析。
所有患者在医生整体评估和患者满意度评分方面均显示出临床改善。在客观生物物理测量中，发现皮肤水合作用和粗糙度有所改善。组织学检查显示真皮厚度、真皮胶原蛋白含量和真皮原纤维蛋白含量显著增加。副作用极小。
局限性在于患者数量少且缺乏长期随访。
微针分数射频是一种对亚洲人安全有效的皮肤年轻化方法。
