Oaro Dermatology Clinic, Seoul, Korea.
Department of Dermatology, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, Korea.
J Eur Acad Dermatol Venereol. 2018 Apr;32(4):639-644. doi: 10.1111/jdv.14714. Epub 2017 Dec 15.
While device-based acne treatments are widely applied for patients not tolerating conventional medications, related controlled studies have been still limited. Recently, non-ablative 1450-nm diode laser (DL) and fractional microneedling radiofrequency (FMR) have been effectively used for acne, in addition to well-recognized dermal remodelling effects.
To compare the clinical course of acne treatment between DL and FMR.
Twenty-five Korean patients with mild-to-moderate facial acne completed treatments with DL and FMR through a 20-week, randomized split-face study. One randomly assigned half side of each patient's face received DL and the other side by FMR. Treatments were scheduled to receive three consecutive sessions at 4-week intervals. Objective assessments including revised Leeds grades, lesion counts, sebum output measurements, and patients' subjective satisfaction were investigated.
Both DL and FMR demonstrated steady improvement of acne and seborrhoea during treatment sessions. While results between two devices were similar during treatment sessions, FMR was superior to DL in the 12-week follow-up. Patients' subjective assessments for seborrhoea improvement were similar between two devices, while those for acne, skin texture, and acne scars were more satisfactory for FMR. For safety profile, no significant difference was observed between two regimens, while mild postinflammatory hyperpigmentation was observed only in DL side.
Both DL and FMR demonstrated efficacies for acne and seborrhoea, with reasonable safety profile. FMR was more effective than DL for the long-term maintenance, and subjective assessments for texture and scar improvements. Therefore, a few sessions of these devices would be a viable option for acne treatments.
虽然基于器械的痤疮治疗方法在不能耐受常规药物的患者中得到广泛应用，但相关对照研究仍较为有限。最近，非剥脱性 1450nm 二极管激光（DL）和分 段式微针射频（FMR）除了具有公认的皮肤重塑效果外，也已被有效地用于治疗痤疮。
比较 DL 和 FMR 治疗痤疮的临床过程。
25 例轻中度面部痤疮患者通过 20 周的随机分组对照研究完成了 DL 和 FMR 治疗。每位患者的一侧脸随机接受 DL 治疗，另一侧脸接受 FMR 治疗。治疗方案为每 4 周连续接受 3 次治疗。客观评估包括修订后的利兹评分、皮损计数、皮脂分泌测量和患者的主观满意度。
DL 和 FMR 在治疗过程中均显示痤疮和皮脂溢的持续改善。虽然两种设备在治疗过程中的结果相似，但在 12 周的随访中，FMR 优于 DL。患者对皮脂溢改善的主观评估在两种设备之间相似，而对痤疮、皮肤质地和痤疮疤痕的改善，FMR 更令人满意。两种方案的安全性相似，只有 DL 组观察到轻度炎症后色素沉着过度。
DL 和 FMR 均显示出对痤疮和皮脂溢的疗效，具有合理的安全性。FMR 在长期维持方面比 DL 更有效，且在改善质地和疤痕方面的主观评估更令人满意。因此，这些设备的几次治疗可能是痤疮治疗的一种可行选择。
