Reinisch Lou, Garrett C Gaelyn, Courey Mark
School of Arts and Sciences, Farmingdale State College (SUNY), Farmingdale, New York, 11735.
Lasers Surg Med. 2013 Dec;45(10):679-85. doi: 10.1002/lsm.22204. Epub 2013 Nov 19.
The physician using a laser in medicine should have treatment planning software available that will help him or her to better understand the full effects of the laser radiation on the patient, similar to that of a radiation oncologist. Combining this software with imaging scans from the patient, treatments can be optimized for individual patients.
Using off-the-shelf computers and software, we put together a simple system that is able to calculate thermal profiles from laser irradiation using an algorithm that runs in real time on a laptop computer with commercial software. The tissues used in these studies are simulated. We use realistic parameters and add some random blood vessels to the simulated tissue.
We demonstrate in the simulations the temperature profile in tissue after laser irradiation. We can see build up of temperature in tissue irradiated with multiple pulses at 2 Hz repetition rate. The simulations show how the volume of the tissue is important in calculating thermal relaxation times. We also show how temperature relaxes away from small volumes in a short time and longer durations are needed for larger volumes of tissue.
The importance of understanding how a laser interacts fully with the tissue will allow the surgeon to better determine when a laser is appropriate and which laser is optimal for a patient. The results show how these calculations can be made in a simplified fashion. Ultimately, it would be convenient to combine such software with imaging systems for careful laser treatment planning.
在医学中使用激光的医生应具备治疗计划软件,这将有助于其更好地理解激光辐射对患者的全面影响,类似于放射肿瘤学家的情况。将该软件与患者的成像扫描相结合,可为个体患者优化治疗方案。
我们使用现成的计算机和软件,构建了一个简单的系统,该系统能够使用在配备商业软件的笔记本电脑上实时运行的算法,根据激光照射计算热分布。这些研究中使用的组织是模拟的。我们使用实际参数,并在模拟组织中添加一些随机血管。
我们在模拟中展示了激光照射后组织中的温度分布。我们可以看到,以2赫兹重复频率进行多次脉冲照射时,组织中的温度会升高。模拟结果表明,组织体积在计算热弛豫时间时很重要。我们还展示了小体积组织中的温度如何在短时间内弛豫,而大体积组织则需要更长时间。
了解激光与组织如何充分相互作用的重要性,将使外科医生能够更好地确定何时适合使用激光以及哪种激光对患者最为理想。结果表明这些计算可以以简化的方式进行。最终,将此类软件与成像系统相结合以便进行精确的激光治疗计划将非常方便。