Institut für Pharmazeutische Biologie, Universität Heidelberg, Im Neuenheimer Feld 364, D-69120, Heidelberg, Germany.
J Chem Ecol. 1993 Sep;19(9):1889-903. doi: 10.1007/BF00983794.
Sequestration of dietary pyrrolizidine alkaloids (PA) by larvae and adults of six European arctiid moth species (Spilosoma lubricipeda, Arctia caja, Phragmatobia fuliginosa, Callimorpha dominula, Diacrisia sannio, andTyria jacobaeae) was investigated for comparison with the well-studied Asian arctiidCreatonotos transiens. Larvae of all species metabolized free PA bases into the respectiveN-oxides. Only adults ofA. caja, P. fuliginosa, andS. lubricipeda, but not their larvae, converted dietary 7(S)-heliotrine to 7(R)-heliotrine, a direct precursor of a male pheromone in some arctiids, 7(R)-hydroxydanaidal. The larval integument figures as the main storage site for resorbed alkaloids; only minor amounts were found in other tissues. In addition, a significant amount of alkaloid is deposited in the cocoon ofArctia caja; only traces of alkaloids could be found in the meconium and the exuviae of this species. A substantial part of the alkaloids fed was degraded to unknown, nonalkaloidal products.
六种欧洲天幕毛虫（Spilosoma lubricipeda、Arctia caja、Phragmatobia fuliginosa、Callimorpha dominula、Diacrisia sannio 和 Tyria jacobaeae）幼虫和成虫对膳食吡咯里西啶生物碱（PA）的隔离进行了研究，以便与研究充分的亚洲天幕毛虫Creatonotos transiens 进行比较。所有物种的幼虫都将游离 PA 碱代谢为各自的 N-氧化物。只有 A. caja、P. fuliginosa 和 S. lubricipeda 的成虫，而不是它们的幼虫，将膳食中的 7(S)-海胆素转化为 7(R)-海胆素，这是一些天幕毛虫雄性信息素的直接前体，7(R)-羟基大纳丁。幼虫的体壁是吸收的生物碱的主要储存部位；在其他组织中仅发现少量生物碱。此外，大量生物碱沉积在天幕毛虫的茧中；在该物种的胎粪和蜕皮中只能检测到微量的生物碱。摄入的生物碱中有相当一部分被降解为未知的非生物碱产物。
