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非转移性和转移性口腔鳞状细胞癌中的基质肌成纤维细胞：一项免疫组织化学研究。

Stromal myofibroblasts in nonmetastatic and metastatic oral squamous cell carcinoma: An immunohistochemical study.

作者信息

Sridhara Sudheendra Udyavara, Choudaha Nidhi, Kasetty Sowmya, Joshi Prathamesh Satish, Kallianpur Shreenivas, Tijare Manisha

机构信息

Department of Oral Pathology, People's College of Dental Sciences and Research Centre, Bhopal, Madhya Pradesh, India.

出版信息

J Oral Maxillofac Pathol. 2013 May;17(2):190-4. doi: 10.4103/0973-029X.119758.

DOI:10.4103/0973-029X.119758
PMID:24250077
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3830225/
Abstract

BACKGROUND AND AIMS

Myofibroblasts are one of the important components of the tumor microenvironment which could possibly play an important role in tumor progression. The purpose of this study was to compare the presence of α-smooth muscle actin (α-SMA) and CD34 positive fibroblasts in nonmetastatic and metastatic oral squamous cell carcinoma and to evaluate their role in tumor metastasis.

MATERIALS AND METHODS

Ten cases each of histologically proven metastatic and nonmetastatic oral squamous cell carcinoma formed the study group. The tissue sections were stained immunohistochemically for α-SMA and CD34. The stromal spindle cells positive for these markers in the study groups were counted and compared.

RESULTS

α-SMA positive cases were more in the metastatic group and CD34 positive cases were found to be more in the nonmetastatic tumors.

CONCLUSIONS

Though difference in the staining pattern was statistically nonsignificant, the inverse relationship between α-SMA and CD34 positive cells is indicative of dynamic nature and the influence of tumor stroma in tumor progression and metastasis.

摘要

背景与目的

肌成纤维细胞是肿瘤微环境的重要组成部分之一，可能在肿瘤进展中发挥重要作用。本研究旨在比较α-平滑肌肌动蛋白（α-SMA）和CD34阳性成纤维细胞在非转移性和转移性口腔鳞状细胞癌中的存在情况，并评估它们在肿瘤转移中的作用。

材料与方法

选取经组织学证实的转移性和非转移性口腔鳞状细胞癌各10例组成研究组。组织切片进行α-SMA和CD34免疫组织化学染色。对研究组中这些标志物阳性的基质梭形细胞进行计数并比较。

结果

转移性组中α-SMA阳性病例更多，非转移性肿瘤中CD34阳性病例更多。

结论

尽管染色模式的差异在统计学上无显著意义，但α-SMA和CD34阳性细胞之间的负相关关系表明了肿瘤基质在肿瘤进展和转移中的动态性质及影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bcf/3830225/40470903173c/JOMFP-17-190-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bcf/3830225/794f75522e22/JOMFP-17-190-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bcf/3830225/2f06928d8abc/JOMFP-17-190-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bcf/3830225/f5be421e345a/JOMFP-17-190-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bcf/3830225/d3d49a076947/JOMFP-17-190-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bcf/3830225/e0e64008956a/JOMFP-17-190-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bcf/3830225/40470903173c/JOMFP-17-190-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bcf/3830225/794f75522e22/JOMFP-17-190-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bcf/3830225/2f06928d8abc/JOMFP-17-190-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bcf/3830225/f5be421e345a/JOMFP-17-190-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bcf/3830225/d3d49a076947/JOMFP-17-190-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bcf/3830225/e0e64008956a/JOMFP-17-190-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bcf/3830225/40470903173c/JOMFP-17-190-g007.jpg

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