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吉兰-巴雷综合征并发罕见的电解质紊乱。

Uncommon dyselectrolytemia complicating Guillain-Barré syndrome.

作者信息

Saroja Aralikatte Onkarappa, Naik Karkal Ravishankar, Khanpet Mallikarjun S

机构信息

Department of Neurology, KLE University's Jawaharlal Nehru Medical College and KLES', Dr. Prabhakar Kore Hospital and MRC, Nehrunagar, Belgaum - 590 010, India.

出版信息

J Neurosci Rural Pract. 2013 Jul;4(3):328-30. doi: 10.4103/0976-3147.118794.

DOI:10.4103/0976-3147.118794
PMID:24250175
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3821428/
Abstract

Guillain-Barré syndrome (GBS) and hypokalemic paralysis are common causes of acute flaccid quadriparesis and specific therapeutic interventions differ. Simultaneous occurrence of severe hypokalemia in patients with GBS at the time of presentation can cause diagnostic and therapeutic dilemma. Presence of hypomagnesemia with hypokalemia in patients with GBS can be perplexing and pose further challenges. Evaluation for preexisting inherited or other associated metabolic disturbances is needed in the presence of such complex dyselectrolytemia. We report the rare association of GBS with severe hypokalemia and hypomagnesemia in a 41-year-old male presenting with acute flaccid quadriparesis and the therapeutic challenges faced.

摘要

吉兰-巴雷综合征(GBS)和低钾性麻痹是急性弛缓性四肢瘫的常见病因,且具体治疗干预措施有所不同。GBS患者在发病时同时出现严重低钾血症可导致诊断和治疗困境。GBS患者合并低镁血症和低钾血症可能令人困惑,并带来更多挑战。在存在这种复杂的电解质紊乱时,需要评估是否存在既往遗传性或其他相关代谢紊乱。我们报告了一名41岁男性,以急性弛缓性四肢瘫就诊,其罕见地合并了GBS与严重低钾血症和低镁血症,以及所面临的治疗挑战。

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引用本文的文献

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Hypokalaemia with Guillain-Barré syndrome: a diagnostic and therapeutic challenge.格林-巴利综合征伴低钾血症:诊断和治疗的挑战。
BMJ Case Rep. 2022 Jun 27;15(6):e249473. doi: 10.1136/bcr-2022-249473.
2
Gitelman syndrome: a rare life-threatening case of hypokalemic paralysis mimicking Guillain-Barré syndrome during pregnancy and review of the literature.吉特曼综合征:一例罕见的危及生命的低钾性麻痹病例,在孕期酷似吉兰-巴雷综合征并文献复习
Clin Case Rep. 2017 Aug 17;5(10):1597-1603. doi: 10.1002/ccr3.1122. eCollection 2017 Oct.
3
Commentary.评论
J Neurosci Rural Pract. 2013 Jul;4(3):332-3.
4
Commentary.评论
J Neurosci Rural Pract. 2013 Jul;4(3):331-2.

本文引用的文献

1
Diagnosis of hypokalemia: a problem-solving approach to clinical cases.低钾血症的诊断:临床病例的解决方法
Iran J Kidney Dis. 2008 Jul;2(3):115-22.
2
Hypokalemic paralysis due to primary hyperaldosteronism simulating Gitelman's syndrome.原发性醛固酮增多症所致低钾性麻痹,酷似吉特曼综合征。
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Gitelman syndrome.吉特曼综合征
Orphanet J Rare Dis. 2008 Jul 30;3:22. doi: 10.1186/1750-1172-3-22.
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Reversible electrophysiological abnormalities in hypokalemic periodic paralysis.低钾性周期性麻痹中的可逆性电生理异常
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Guillain-Barré syndrome.吉兰-巴雷综合征
Lancet. 2005 Nov 5;366(9497):1653-66. doi: 10.1016/S0140-6736(05)67665-9.
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Profound ionized hypomagnesemia induced by therapeutic plasma exchange in liver failure patients.
Transfusion. 2002 Dec;42(12):1598-602. doi: 10.1046/j.1537-2995.2002.00247.x.
7
Gitelman's syndrome revisited: an evaluation of symptoms and health-related quality of life.再探吉特曼综合征:症状及健康相关生活质量评估
Kidney Int. 2001 Feb;59(2):710-7. doi: 10.1046/j.1523-1755.2001.059002710.x.
8
Dysfunction of sensory nerves during attacks of hypokalemic periodic paralysis.低钾性周期性麻痹发作期间感觉神经功能障碍。
Neuromuscul Disord. 1999 Jun;9(4):227-31. doi: 10.1016/s0960-8966(98)00129-1.
9
Novel mutations in the thiazide-sensitive NaCl cotransporter gene in patients with Gitelman syndrome with predominant localization to the C-terminal domain.吉特曼综合征患者中噻嗪类敏感型氯化钠共转运体基因的新型突变,主要定位于C末端结构域。
Kidney Int. 1998 Sep;54(3):720-30. doi: 10.1046/j.1523-1755.1998.00070.x.