Sanyal Debmalya, Raychaudhuri Moutusi
Department of Endocrinology, KPC Medical College, Kolkata, West Bengal, India.
Indian J Endocrinol Metab. 2013 Oct;17(Suppl 1):S252-3. doi: 10.4103/2230-8210.119590.
Addison's disease or primary adrenal insufficiency (PAI) is a rare manifestation of antiphospholipid syndrome (APS). PAI is the most common among the endocrinologic manifestations and can also rarely be the presenting symptom of APS. Venous thrombosis and/or adrenal hemorrhage are the leading cause of PAI in APS. Autoimmune adrenal failure is postulated to be another possible mechanism. We report a case of PAI in a 44-year-old lady preceding primary APS, probably autoimmune, without any evidence of adrenal hemorrhage or infarction. High index of clinical suspicion for PAI in APS is needed; conversely APS should be considered as a possible pathogenetic process in patients presenting with Addison's disease where the etiology is not obvious.
艾迪生病或原发性肾上腺功能不全（PAI）是抗磷脂综合征（APS）的一种罕见表现。PAI是内分泌表现中最常见的，也很少作为APS的首发症状。静脉血栓形成和/或肾上腺出血是APS中PAI的主要原因。自身免疫性肾上腺衰竭被认为是另一种可能的机制。我们报告一例44岁女性原发性APS之前发生PAI的病例，可能是自身免疫性的，没有任何肾上腺出血或梗死的证据。对于APS患者，需要高度怀疑PAI；相反，对于病因不明的艾迪生病患者，应考虑APS是一种可能的致病过程。
