Satta M A, Corsello S M, Della Casa S, Rota C A, Pirozzi B, Colasanti S, Cina G, Grossman A B, Barbarino A
Departments of Endocrinology and Clinical Surgery, Catholic University, Rome.
Clin Endocrinol (Oxf). 2000 Jan;52(1):123-6. doi: 10.1046/j.1365-2265.2000.00903.x.
We describe a 60-year-old man who developed clinical symptoms and signs of Addison's disease, which was subsequently confirmed biochemically; no cause was apparent. Several months later the patient represented with a fit, followed by a large and extensive venous thrombosis in the right iliac vein and in the veins of the right leg. He had strongly positive antibodies to cardiolipin, strongly suggesting a diagnosis of primary antiphospholipid syndrome. While Addison's disease is a well-recognized, albeit rare, manifestation of the antiphospholipid syndrome, the Addison's disease preceded other clinical evidence of the syndrome by several months, in our patient, at variance with previous cases described in the literature. The antiphospholipid syndrome should be considered as a possible pathogenetic process in patients presenting with Addison's disease where the aetiology is not obvious.
我们描述了一名60岁男性，他出现了艾迪生病的临床症状和体征，随后经生化检查得以确诊；病因不明。几个月后，该患者突然发病，随后右侧髂静脉及右腿静脉出现广泛的大血栓形成。他的抗心磷脂抗体呈强阳性，强烈提示原发性抗磷脂综合征的诊断。虽然艾迪生病是抗磷脂综合征一种公认的、尽管罕见的表现，但在我们的患者中，艾迪生病比该综合征的其他临床证据早出现数月，这与文献中描述的先前病例不同。对于病因不明的艾迪生病患者，应考虑抗磷脂综合征可能作为一种致病过程。
