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糖尿病的围产期管理。

Peripartum management of diabetes.

作者信息

Kalra Pramila, Anakal Manjunath

机构信息

Department of Endocrinology, M S Ramaiah Medical College and Hospitals, Bengaluru, Karnataka, India.

出版信息

Indian J Endocrinol Metab. 2013 Oct;17(Suppl 1):S72-6. doi: 10.4103/2230-8210.119510.

Abstract

The peripartum control of diabetes is very important for the well-being of the newborn as higher incidence of neonatal hypoglycemia is seen if maternal hyperglycemia happens during this period. Type of diabetes (type 1, type 2 or gestational diabetes) also has an effect on the glucose concentration during intrapartum period. During the latent phase of labor, the metabolic demands are stable but during active labor there is increased metabolic demand and decreased insulin requirement. After delivery once the placenta is extracted, insulin resistance rapidly comes down and in patients with pre-gestational diabetes there will be a sudden drop in insulin requirement and the insulin may not be required in women with gestational diabetes, but they just need close monitoring. During breast-feeding blood glucose levels fall because of high metabolic demand and women need to take extra calories to maintain the levels and more vigilance especially in type 1 and type 2 diabetic mothers is required. The protocols used for the management of peripartum management of diabetes mostly rely on glucose and insulin infusion to maintain maternal blood sugars between 70 and 110 mg/dl. The data is mostly from retrospective studies and few randomized control trials done mainly in type 1 diabetes patients. The review summarizes guidelines, which are used for peripartum management of blood glucose.

摘要

围产期糖尿病管理对于新生儿的健康非常重要,因为如果在此期间发生母亲高血糖,新生儿低血糖的发生率会更高。糖尿病类型(1型、2型或妊娠期糖尿病)也会对产时血糖浓度产生影响。在潜伏期,代谢需求稳定,但在活跃期,代谢需求增加,胰岛素需求减少。分娩后,一旦胎盘娩出,胰岛素抵抗迅速下降,孕前糖尿病患者的胰岛素需求会突然降低,妊娠期糖尿病女性可能不再需要胰岛素,但她们需要密切监测。在母乳喂养期间,由于代谢需求高,血糖水平会下降,女性需要摄入额外的热量来维持血糖水平,尤其是1型和2型糖尿病母亲需要更加警惕。用于围产期糖尿病管理的方案大多依靠输注葡萄糖和胰岛素,以使母亲血糖维持在70至110毫克/分升之间。这些数据大多来自回顾性研究,主要针对1型糖尿病患者进行的随机对照试验较少。本综述总结了用于围产期血糖管理的指南。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee45/3830373/2946ba4e2125/IJEM-17-72-g001.jpg

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