Goyal Gagan, Garg Tarun, Malik Basant, Chauhan Gaurav, Rath Goutam, Goyal Amit K
a Department of Pharmaceutics, ISF College of Pharmacy, Moga , Punjab Technical University , Jalandhar , Punjab , India.
Drug Deliv. 2015 Dec;22(8):1027-1042. doi: 10.3109/10717544.2013.855277. Epub 2013 Nov 20.
Benzoyl peroxide (BPO) is generally considered as first line treatment against acne. Low water solubility and formation of larger clusters and limited skin permeation upon topical application necessitates the application of high amount of drug for desired action which leads to induction of skin irritation. In the present study, we developed BPO-loaded niosomal formulation to improve its permeation through skin. The niosomes were further loaded in the carbopol gel to improve contact time. The results of the skin permeation study, skin retention study revealed that niosomes can effectively improve the drug permeation through skin. Application of niosomal gel significantly reduced the bacterial load after a treatment of four days. This reduction in bacterial load was further resulted in a significant reduction in the inflammation with minimal skin irritation compared with plain drug and the plain niosomal formulation.
过氧化苯甲酰（BPO）通常被认为是治疗痤疮的一线药物。其水溶性低，会形成较大的聚集体，局部应用时皮肤渗透性有限，因此需要大量用药才能达到预期效果，这会导致皮肤刺激。在本研究中，我们开发了负载BPO的脂质体剂型以提高其经皮渗透性。脂质体进一步负载于卡波姆凝胶中以延长接触时间。皮肤渗透研究和皮肤滞留研究结果表明，脂质体可有效提高药物经皮渗透性。脂质体凝胶应用四天后可显著降低细菌载量。与普通药物和普通脂质体制剂相比，细菌载量的降低进一步导致炎症显著减轻，且皮肤刺激最小。
