铜催化的苯并噻唑与苯乙酸和 α-羟基苯乙酸的氧化脱羧芳基化反应，以 O2 为唯一氧化剂。
Copper-catalyzed oxidative decarboxylative arylation of benzothiazoles with phenylacetic acids and α-hydroxyphenylacetic acids with O2 as the sole oxidant.
机构信息
School of Biomedical Sciences at Huaqiao Univeristy , Xiamen, Fujian, 361021, China.
出版信息
Org Lett. 2013 Dec 6;15(23):5990-3. doi: 10.1021/ol402871f. Epub 2013 Nov 19.
PMID:24251373
Abstract
A Cu(II)-catalyzed oxidative decarboxylative synthesis of 2-aryl benzothiazole from phenylacetic acids and α-hydroxyphenylacetic acids has been developed. This reaction proceeds via Cu(II)-catalyzed decarboxylation, C-H bond oxidation, ring-opening, and condensation steps in a one-pot protocol with dioxygen as the sole terminal oxidant. Various functional groups were tolerated under standard conditions, and isolated yields were as high as 95%.
摘要
一种铜（II）催化的从苯乙酸和α-羟基苯乙酸合成 2-芳基苯并噻唑的氧化脱羧反应已经被开发出来。该反应通过一锅法在铜（II）催化下进行脱羧、C-H 键氧化、开环和缩合步骤，以氧气为唯一的终端氧化剂。在标准条件下，各种官能团都能耐受，分离产率高达 95%。
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