Teerlink John R, Alburikan Khalid, Metra Marco, Rodgers Jo E
Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, CB# 7569, Chapel Hill, NC 27599, USA.
Curr Cardiol Rev. 2015;11(1):53-62. doi: 10.2174/1573403x09666131117174414.
Acute decompensated heart failure (ADHF) continues to increase in prevalence and is associated with substantial mortality and morbidity including frequent hospitalizations. The American Heart Association is predicting that more than eight million Americans will have heart failure by 2030 and that the total direct costs associated with the disease will rise from $21 billion in 2012 to $70 billion in 2030. The increase in the prevalence and cost of HF is primarily the result of shifting demographics and a growing population. Although many large, randomized, controlled clinical trials have been conducted in patients with chronic heart failure, it was not until recently that a growing number of studies began to address the management of ADHF. It is the intent of this review to update the clinician regarding the evaluation and optimal management of ADHF.
急性失代偿性心力衰竭(ADHF)的患病率持续上升,与包括频繁住院在内的大量死亡率和发病率相关。美国心脏协会预测,到2030年,超过800万美国人将患有心力衰竭,与该疾病相关的总直接成本将从2012年的210亿美元升至2030年的700亿美元。心力衰竭患病率和成本的增加主要是人口结构变化和人口增长的结果。尽管已经对慢性心力衰竭患者进行了许多大型随机对照临床试验,但直到最近,越来越多的研究才开始关注ADHF的管理。本综述旨在向临床医生介绍ADHF的评估和最佳管理的最新情况。