室温下 α-三氟甲基化酯与末端烯烃的有机催化反应。
Organocatalytic reactions of α-trifluoromethylated esters with terminal alkenes at room temperature.
机构信息
Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences , 345 Lingling Road, Shanghai 200032, P. R. China.
出版信息
J Org Chem. 2013 Dec 20;78(24):12525-31. doi: 10.1021/jo402212j. Epub 2013 Nov 22.
PMID:24251733
Abstract
CF3-containing esters smoothly reacted with electron-deficient alkenes in the presence of a phosphine (2-dicyclohexylphosphino-2',4',6'-triisopropylbiphenyl) organocatalyst at room temperature in an aerobic atmosphere. These Michael reactions efficiently provided products with a CF3 quaternary carbon center.
摘要
含 CF3 的酯在室温、有氧条件下，在膦（2-二环己基膦-2'，4'，6'-三异丙基联苯）有机催化剂的存在下与缺电子烯烃平稳反应。这些迈克尔加成反应高效地提供了具有 CF3 季碳原子中心的产物。
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