无金属、有机催化的烯烃双乙酰氧基化反应。
Metal-free, organocatalytic syn diacetoxylation of alkenes.
机构信息
The State Key Laboratory of Natural and Biomimetic Drugs, Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing 100191, P.R. China.
出版信息
Org Lett. 2012 Jul 6;14(13):3336-9. doi: 10.1021/ol301311e. Epub 2012 Jun 12.
PMID:22690888
Abstract
A novel method for the organocatalytic syn diacetoxylation of alkenes has been developed using aryl iodides as efficient catalysts. A broad range of substrates, including electron-rich as well as electron-deficient alkenes, are smoothly transformed by the new procedure, furnishing the desired products in good to excellent yields with high diastereoselectivity (up to >19:1 dr).
摘要
一种使用芳基碘化物作为高效催化剂的烯烃的新型有机催化顺二乙酰氧化方法已经被开发出来。该新方法能够顺利转化包括富电子和缺电子烯烃在内的广泛底物，以高至>19:1 dr 的优异对映选择性得到良好至优秀收率的所需产物。
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