可见的光氧化还原在均裂芳香取代反应中的应用：芳基卤化物与芳烃的直接芳基化。
Visible-light photoredox in homolytic aromatic substitution: direct arylation of arenes with aryl halides.
机构信息
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering, and Materials Science, Soochow University, 199 RenAi Road, Suzhou, Jiangsu 215123, China.
出版信息
Org Lett. 2013 Jun 7;15(11):2664-7. doi: 10.1021/ol400946k. Epub 2013 May 21.
Direct arylation of unactivated arenes or heteroarenes with aryl halides could be carried out in the presence of potassium tert-butoxide and dimethyl sulfoxide under visible-light irradiation. Ir(ppy)3 was found to be an effective photoredox catalyst for this reaction. The reactions of aryl iodides occurred at room temperature. Elevated temperature was required for aryl bromides. Homolytic aromatic substitution was proposed to be the operative reaction pathway.
在叔丁醇钾和二甲基亚砜的存在下，在可见光照射下，未活化的芳基或杂芳基与芳基卤化物可以进行直接芳基化反应。Ir(ppy)3 被发现是该反应的有效光氧化还原催化剂。芳基碘化物的反应可以在室温下进行。对于芳基溴化物，则需要升高温度。提出了均裂芳香取代是可行的反应途径。
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