Tousen Yuko, Wolber Frances M, Chua Wei-Hang, Tadaishi Miki, Ishimi Yoshiko, Kruger Marlena C
Department of Food Function and Labeling, National Institute of Health and Nutrition , Toyama, Shinjuku-ku, Tokyo , Japan and.
Int J Food Sci Nutr. 2014 May;65(3):360-7. doi: 10.3109/09637486.2013.858238. Epub 2013 Nov 19.
In this study, we investigated the synergistic effects of daidzein (Dz) and kiwifruit on bone and equol production in ovariectomised (OVX) rats. Female Sprague-Dawley rats were randomly assigned to one of five groups: sham operated, OVX control, OVX fed 0.1% Dz-supplemented diet (OVX + Dz), OVX fed 0.1% Dz and green kiwifruit (GRK)-supplemented diet (OVX + Dz + GRK) and OVX fed 0.1% Dz and gold kiwifruit (GOK)-supplemented diet (OVX + Dz + GOK). There were no significant differences in whole body and femur bone mineral density (BMD) among groups at week 8. BMD in the OVX group significantly decreased at week 8; however, BMD in the OVX + Dz + GRK was not significantly different from baseline in the end of the study. However, supplementation with kiwifruit did not affect urinary equol concentrations, urinary ratios of equol to Dz and the composition of caecal microbiota. These results suggest that the combination of Dz and GRK may slightly reduce bone loss caused by oestrogen deficiency but does not affect equol production.
在本研究中，我们调查了大豆苷元（Dz）和猕猴桃对去卵巢（OVX）大鼠骨骼及雌马酚生成的协同作用。将雌性斯普拉格-道利大鼠随机分为五组之一：假手术组、OVX对照组、喂食含0.1% Dz补充剂饮食的OVX组（OVX + Dz）、喂食含0.1% Dz和绿色猕猴桃（GRK）补充剂饮食的OVX组（OVX + Dz + GRK）以及喂食含0.1% Dz和金色猕猴桃（GOK）补充剂饮食的OVX组（OVX + Dz + GOK）。在第8周时，各组间全身和股骨骨矿物质密度（BMD）无显著差异。OVX组的BMD在第8周时显著降低；然而，在研究结束时，OVX + Dz + GRK组的BMD与基线相比无显著差异。然而，补充猕猴桃并不影响尿中雌马酚浓度、尿中雌马酚与Dz的比值以及盲肠微生物群的组成。这些结果表明，Dz和GRK的组合可能会略微减少雌激素缺乏引起的骨质流失，但不影响雌马酚的生成。
