Azuma Naoto, Katada Yoshinori, Kitano Sachie, Sekiguchi Masahiro, Kitano Masayasu, Nishioka Aki, Hashimoto Naoaki, Matsui Kiyoshi, Iwasaki Tsuyoshi, Sano Hajime
Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine , Nishinomiya, Hyogo , Japan.
Mod Rheumatol. 2014 Jul;24(4):626-32. doi: 10.3109/14397595.2013.850766. Epub 2013 Nov 5.
To assess changes in salivary epidermal growth factor (EGF) levels and the correlation between these levels and the severity of intraoral manifestations in Sjögren's syndrome (SS).
Forty SS patients and 23 controls were enrolled. Salivary EGF concentration was measured using an enzyme-linked immunosorbent assay, and intraoral manifestations were evaluated using a short version of the Oral Health Impact Profile (OHIP-14). The associations among salivary flow rate, EGF levels and the severity of intraoral manifestations were analyzed.
The total salivary EGF output was significantly decreased in the SS patients compared with the controls (9237.6 ± 8447.0 vs. 13296.9 ± 7907.1 pg/10 min, respectively, p = 0.033). In the SS patients, total EGF output and salivary flow rate showed a strong positive correlation (rs = 0.824, p = 0.0005), while total EGF output and disease duration showed a negative correlation (rs = -0.484, p = 0.008). Further, total EGF output was significantly correlated with the OHIP-14 score (rs = -0.721, p = 0.012).
The salivary flow rate and EGF levels are decreased in SS, and this deterioration in saliva quality causes refractory intraoral manifestations. Our findings have provided new therapeutic targets for SS.
评估干燥综合征（SS）患者唾液表皮生长因子（EGF）水平的变化及其与口腔内表现严重程度之间的相关性。
纳入40例SS患者和23例对照。采用酶联免疫吸附测定法测量唾液EGF浓度，使用简化版口腔健康影响程度量表（OHIP-14）评估口腔内表现。分析唾液流速、EGF水平与口腔内表现严重程度之间的关联。
与对照组相比，SS患者的唾液EGF总输出量显著降低（分别为9237.6±8447.0与13296.9±7907.1 pg/10分钟，p = 0.033）。在SS患者中，EGF总输出量与唾液流速呈强正相关（rs = 0.824，p = 0.0005），而EGF总输出量与病程呈负相关（rs = -0.484，p = 0.008）。此外，EGF总输出量与OHIP-14评分显著相关（rs = -0.721，p = 0.012）。
SS患者的唾液流速和EGF水平降低，唾液质量的这种恶化导致难治性口腔内表现。我们的研究结果为SS提供了新的治疗靶点。
