Programa de Pós-Graduação em Farmácia, Faculdade de Farmácia, Universidade Federal da Bahia, Brazil.
Hospital Ana Nery, Faculdade de Medicina da Bahia, Universidade Federal da Bahia, Brazil.
Int Immunopharmacol. 2014 Jan;18(1):66-70. doi: 10.1016/j.intimp.2013.11.003. Epub 2013 Nov 16.
The anti-inflammatory effect of 3-hydroxy-3-methyl-glutaryl-CoA reductase inhibitors (statins) has been investigated in dyslipidemic patients treated with these pharmacologic agents. The aim of this study was to investigate the serum levels of cytokines and chemokines that have been associated with atherosclerosis and cardiovascular disease in Brazilian patients treated for hypercholesterolemia with statin. The serum levels of the cytokines IL-1β, IL-6, IL-10, TNF-α and TGF-β, and the levels of the chemokines IL-8 (CXCL8) and MCP-1 were determined by enzyme-linked immunosorbent assay and tested for their association with cardiovascular disease. The suppression of circulating levels of TNF-α, MCP-1 and IL-8 and their enhancing effect on IL-10 and TGF-β production were more pronounced in male patients. Female patients treated with statins who had a previous myocardial infarction presented higher median levels of both TNF-α and IL-8 (P<0.05) and a lower median level of IL-10 than female patients without MI (P<0.05). Except in women with a previous myocardial infarction, the treatment of dyslipidemic Brazilian patients with statins down-modulates the production of atherogenic cytokines and chemokines and increases the circulating levels of anti-atherogenic cytokines.
他汀类药物（3-羟基-3-甲基戊二酰辅酶 A 还原酶抑制剂）的抗炎作用已在接受这些药物治疗的血脂异常患者中得到研究。本研究旨在调查与动脉粥样硬化和心血管疾病相关的细胞因子和趋化因子在接受他汀类药物治疗高胆固醇血症的巴西患者中的血清水平。通过酶联免疫吸附试验测定细胞因子 IL-1β、IL-6、IL-10、TNF-α 和 TGF-β 以及趋化因子 IL-8（CXCL8）和 MCP-1 的血清水平，并检测其与心血管疾病的相关性。在男性患者中，他汀类药物对循环 TNF-α、MCP-1 和 IL-8 的抑制作用以及对 IL-10 和 TGF-β 产生的增强作用更为明显。与无 MI 的女性患者相比，既往心肌梗死的女性患者的 TNF-α 和 IL-8 中位数水平更高（P<0.05），而 IL-10 中位数水平更低（P<0.05）。除了既往有心肌梗死的女性患者外，用他汀类药物治疗血脂异常的巴西患者可下调致动脉粥样硬化细胞因子和趋化因子的产生，并增加循环中抗动脉粥样硬化细胞因子的水平。
