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Properties of monospecific antibodies to the glycoprotein of western equine encephalitis virus.

作者信息

Yamamoto K

出版信息

Microbiol Immunol. 1986;30(4):343-51. doi: 10.1111/j.1348-0421.1986.tb00951.x.

DOI:10.1111/j.1348-0421.1986.tb00951.x
PMID:2425229
Abstract

Monospecific (MSp-) antisera against E1 and E2 glycoproteins of western equine encephalitis (WEE) virus were prepared and examined for binding activities to whole virions, hemagglutination-inhibition (HI), neutralization (NT) and protection. Both anti-E1 and anti-E2 MSp-Abs protected mice against WEE virus challenge. A competition experiment with monoclonal antibodies showed that these MSp-antisera appear to lack the antibody population for some epitopes involved in viral neutralization.

摘要

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