基于 3-羧基吡唑的新型锌配合物的体内潜在抗糖尿病活性。
In vivo potential antidiabetic activity of a novel zinc coordination compound based on 3-carboxy-pyrazole.
机构信息
Departamento de Química Inorgánica, Universidad de Granada, Avda Fuentenueva s/n, 18071 Granada, Spain.
Instituto de Parasitología y Biomedicina López-Neyra, CSIC, Avenida del Conocimiento S.N., Armilla, Granada, Spain.
出版信息
J Inorg Biochem. 2014 Feb;131:64-7. doi: 10.1016/j.jinorgbio.2013.10.019. Epub 2013 Oct 30.
A novel Zn mononuclear complex with 3-carboxy-pyrazole ligand has been prepared using conventional routes and characterized by X-ray diffraction. The structure consists of discrete neutral [Zn(C6H3N2O2)2(H2O)2] molecules held together by hydrogen interactions. This compound exhibits a potential in vivo antidiabetic activity and the in vitro toxicity can be considered negligible.
一种新型的含 3-羧基吡唑配体的锌单核配合物已通过常规路线合成，并通过 X 射线衍射进行了表征。该结构由离散的中性[Zn(C6H3N2O2)2(H2O)2]分子通过氢键相互作用连接而成。该化合物具有体内抗糖尿病活性的潜力，体外毒性可认为可忽略不计。
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