Saito Masafumi, Nemoto Tohru, Tobimatsu Satoshi, Ebata Midori, Le Yulan, Nakajima Kei
Division of Clinical Nutrition, Department of Medical Dietetics, Faculty of Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, Saitama 350-0295, Japan.
J Nutr Metab. 2011;2011:146865. doi: 10.1155/2011/146865. Epub 2011 Jun 16.
Recently it has been reported that the estimated glomerular filtration rate (eGFR) is higher in habitual coffee consumers than in noncoffee consumers. However, the causality remains unclear. Therefore, we conducted a clinical trial to investigate the effects of coffee consumption on kidney function. Nineteen asymptomatic nonsmokers aged 21-27 years old participated in this study. They consumed coffee (18 g coffee beans/450 mL per day) or green tea as a comparator for 2 weeks in a crossover design. Although creatinine-based eGFR was not affected after consuming either beverage, all cystatin-C-based eGFRs determined using five different equations were significantly increased after coffee consumption (means: 5.0-7.7%), but not after green tea consumption (means: 0.1-1.6%). Serum adiponectin and magnesium levels increased significantly after coffee consumption (means: 13.6% and 4.3%, resp.), but not after green tea consumption. These findings suggest that even a short period of coffee consumption may increase cystatin-C-based eGFR, along with favorable changes in serum adiponectin, in healthy young adults.
最近有报道称，习惯性饮用咖啡者的估算肾小球滤过率（eGFR）高于不饮用咖啡者。然而，因果关系仍不明确。因此，我们进行了一项临床试验，以研究饮用咖啡对肾功能的影响。19名年龄在21至27岁之间的无症状非吸烟者参与了本研究。他们采用交叉设计，饮用咖啡（每天18克咖啡豆/450毫升）或绿茶作为对照，为期2周。虽然饮用两种饮料后基于肌酐的eGFR均未受影响，但饮用咖啡后，使用五种不同方程测定的所有基于胱抑素C的eGFR均显著升高（均值：5.0 - 7.7%），而饮用绿茶后则未升高（均值：0.1 - 1.6%）。饮用咖啡后血清脂联素和镁水平显著升高（均值分别为13.6%和4.3%），而饮用绿茶后则未升高。这些研究结果表明，即使是短时间饮用咖啡，也可能会使健康年轻成年人中基于胱抑素C的eGFR升高，同时血清脂联素也会发生有利变化。
