Vite-Garín Tania, Estrada-Bárcenas Daniel Alfonso, Cifuentes Joaquín, Taylor Maria Lucia
Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), México DF, Mexico.
Colección Nacional de Cultivos Microbianos, Centro de Investigación y de Estudios Avanzados, Instituto Politécnico Nacional, México DF, Mexico.
Rev Iberoam Micol. 2014 Jan-Mar;31(1):11-5. doi: 10.1016/j.riam.2013.09.013. Epub 2013 Nov 16.
Advances in the classification of the human pathogen Histoplasma capsulatum (H. capsulatum) (ascomycete) are sustained by the results of several genetic analyses that support the high diversity of this dimorphic fungus. The present mini-review highlights the great genetic plasticity of H. capsulatum. Important records with different molecular tools, mainly single- or multi-locus sequence analyses developed with this fungus, are discussed. Recent phylogenetic data with a multi-locus sequence analysis using 5 polymorphic loci support a new clade and/or phylogenetic species of H. capsulatum for the Americas, which was associated with fungal isolates obtained from the migratory bat Tadarida brasiliensis. This manuscript is part of the series of works presented at the "V International Workshop: Molecular genetic approaches to the study of human pathogenic fungi" (Oaxaca, Mexico, 2012).
人类病原体荚膜组织胞浆菌（一种子囊菌）分类方面的进展得益于多项基因分析结果，这些结果证实了这种双态真菌具有高度多样性。本微型综述着重介绍了荚膜组织胞浆菌巨大的遗传可塑性。文中讨论了使用不同分子工具（主要是针对该真菌开发的单基因座或多基因座序列分析）所取得的重要记录。近期利用5个多态性基因座进行多基因座序列分析获得的系统发育数据支持了美洲地区一种新的荚膜组织胞浆菌进化枝和/或系统发育种，它与从巴西游离尾蝠分离出的真菌菌株有关。本文是在“第五届国际研讨会：人类致病真菌研究的分子遗传学方法”（2012年，墨西哥瓦哈卡）上发表的系列著作的一部分。
