Chestnut D H, Choi W W, Isbell T J
Obstet Gynecol. 1986 Jul;68(1):65-9.
The efficacy of epidurally administered hydromorphone for postcesarean analgesia was evaluated in a prospective, randomized, double-blind study. Patients in group H (N = 26) received 1.0 mg of hydromorphone in preservative-free saline (total volume = 10 mL), administered epidurally. Patients in group B (N = 26) received 10 mL of 0.25% bupivacaine, administered epidurally. Both groups subsequently received intramuscular injections of hydromorphone as needed. There were significant differences between the two groups in pain score, patient assessment of analgesia quality, time to first analgesic intervention, and total dosage of hydromorphone during the first 24 hours. Nausea/vomiting and pruritus occurred more frequently in group H. No patient had a respiratory rate less than or equal to 10. There were no statistically significant differences between groups in mean times to first ambulation, first void, first passage of flatus, or hospital discharge.
在一项前瞻性、随机、双盲研究中评估了硬膜外注射氢吗啡酮用于剖宫产术后镇痛的疗效。H组（N = 26）患者接受1.0 mg氢吗啡酮溶于无防腐剂盐水中（总体积 = 10 mL），经硬膜外给药。B组（N = 26）患者接受10 mL 0.25%布比卡因，经硬膜外给药。两组随后根据需要接受氢吗啡酮肌内注射。两组在疼痛评分、患者对镇痛质量的评估、首次镇痛干预时间以及最初24小时内氢吗啡酮的总剂量方面存在显著差异。H组恶心/呕吐和瘙痒的发生率更高。没有患者的呼吸频率小于或等于10次。两组在首次下床活动、首次排尿、首次排气或出院的平均时间方面没有统计学上的显著差异。
