二价过渡金属离子 paraCEST MRI 对比剂的比较。
Comparison of divalent transition metal ion paraCEST MRI contrast agents.
机构信息
Department of Chemistry, University at Buffalo, Amherst, NY, 14260, USA.
出版信息
J Biol Inorg Chem. 2014 Feb;19(2):191-205. doi: 10.1007/s00775-013-1059-4. Epub 2013 Nov 20.
Abstract
Transition-metal-ion-based paramagnetic chemical exchange saturation transfer (paraCEST) agents are a promising new class of compounds for magnetic resonance imaging (MRI) contrast. Members in this class of compounds include paramagnetic complexes of Fe(II), Co(II), and Ni(II). The development of the coordination chemistry for these paraCEST agents is presented with an emphasis on the choice of the azamacrocycle backbone and pendent groups with the goals of controlling the oxidation state, spin state, and stability of the complexes. Chemical exchange saturation transfer spectra and images are compared for different macrocyclic complexes containing amide or heterocyclic pendent groups. The potential of paraCEST agents that function as pH- and redox-activated MRI probes is discussed.
摘要
基于过渡金属离子的顺磁化学交换饱和转移（paraCEST）试剂是一类有前途的新型磁共振成像（MRI）对比剂。这类化合物包括 Fe(II)、Co(II) 和 Ni(II) 的顺磁配合物。本文介绍了这些 paraCEST 试剂的配位化学发展，重点介绍了选择氮杂大环骨架和带有酰胺或杂环侧基的配体，以控制配合物的氧化态、自旋态和稳定性。比较了含有酰胺或杂环侧基的不同大环配合物的化学交换饱和转移谱和图像。还讨论了作为 pH 和氧化还原激活 MRI 探针的 paraCEST 试剂的潜力。
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