Glazier Virginia E, Panepinto John C
Department of Microbiology and Immunology; Witebsky Center for Microbial Pathogenesis and Immunology; University at Buffalo; The State University of New York; Buffalo, NY USA.
Virulence. 2014 Feb 15;5(2):351-6. doi: 10.4161/viru.27187. Epub 2013 Nov 19.
In all eukaryotic cells, the ER stress response is pivotal to survival and adaptation under stress conditions. During temperature adaptation in the human fungal pathogen Cryptococcus neoformans, ER stress is engaged transiently. Studies of this response have demonstrated that both the engagement (turning on the response), as well as the resolution (turning off the response) are required for temperature adaptation and, therefore, pathogenesis. In this review, we synthesize our current understanding of ER stress response engagement and resolution in C. neoformans during host temperature adaptation with a focus on the posttranscriptional events that regulate it. Identification of fungal-specific and Cryptococcus-specific elements of the evolutionarily conserved ER stress response pathway could lead to identification of anti-fungal targets in this fundamental stress response.
在所有真核细胞中，内质网应激反应对于在应激条件下的生存和适应至关重要。在人类真菌病原体新型隐球菌适应温度的过程中，内质网应激会短暂发生。对这种反应的研究表明，内质网应激反应的启动（开启反应）和消退（关闭反应）对于温度适应以及致病过程都是必需的。在这篇综述中，我们综合了目前对新型隐球菌在宿主温度适应过程中内质网应激反应的启动和消退的理解，重点关注调节该反应的转录后事件。鉴定进化上保守的内质网应激反应途径中的真菌特异性和新型隐球菌特异性元件，可能会在这一基本应激反应中找到抗真菌靶点。
