NatuRA (Natural products and Food Research and Analysis)-Laboratory of Nutrition and Functional Food Science, Department of Pharmaceutical Sciences, University of Antwerp, Antwerpen, Belgium.
Mol Nutr Food Res. 2014 Jan;58(1):211-5. doi: 10.1002/mnfr.201300282. Epub 2013 Nov 20.
The in vivo antioxidant activity of a quantified leaf extract of Cynara scolymus (artichoke) was studied. The aqueous artichoke leaf extract (ALE), containing 1.5% caffeoylquinic acid with chlorogenic acid being most abundant (0.30%), and luteolin-7-O-glucoside as major flavonoid (0.15%), was investigated by evaluating the effect on different oxidative stress biomarkers, after 3 wk oral supplementation in the streptozotocin-induced diabetic rat model. Apart from two test groups (0.2 g ALE/kg BW/day and 1 g ALE/kg BW/day, where BW is body weight), a healthy control group, untreated oxidative stress group, and vitamin E treated group (positive control) were included. A 0.2 g/kg BW/day of ALE decreased oxidative stress: malondialdehyde and 8-hydroxydeoxyguanosine levels significantly diminished, whereas erythrocyte glutathione levels significantly increased. A 1.0 g/kg BW/day ALE did not show higher antioxidant activity.
研究了一种定量的朝鲜蓟（洋蓟）叶提取物的体内抗氧化活性。该水提朝鲜蓟叶提取物（ALE）含有 1.5%的咖啡酰奎宁酸，其中绿原酸含量最丰富（0.30%），芦丁-7-O-葡萄糖苷为主要类黄酮（0.15%）。通过评估其对不同氧化应激生物标志物的影响，研究了其在链脲佐菌素诱导的糖尿病大鼠模型中经 3 周口服补充后的效果。除了两个实验组（0.2 g ALE/kg BW/天和 1 g ALE/kg BW/天，其中 BW 是体重）外，还包括一个健康对照组、未处理的氧化应激组和维生素 E 处理组（阳性对照）。0.2 g/kg BW/天的 ALE 降低了氧化应激：丙二醛和 8-羟基脱氧鸟苷水平显著降低，而红细胞谷胱甘肽水平显著增加。1.0 g/kg BW/天的 ALE 并未显示出更高的抗氧化活性。
