Yönem Özlem, Sivri Bülent, Özdemir Levent, Nadir Işılay, Yüksel Seçkin, Uygun Yasemin
Cumhuriyet University, School of Medicine, Department of Gastroenterology, Sivas, Turkey.
Turk J Gastroenterol. 2013;24(4):303-10. doi: 10.4318/tjg.2013.0256.
BACKGROUND/AIMS: Epidemiological data of gastroesophageal reflux disease from Turkey is scarce. For this reason, we aimed to determine the gastroesophageal reflux disease prevalence in our region and to compare it with both the Western part of Turkey and with other countries in the world.
We used a previously validated reflux questionnaire and applied it to a random sample of 1345 subjects stratified by socio-economic status, who were older than 20 years and were living in the city center of Sivas. The questionnaire was conducted by medical students who were attending Public Health internship.
We estimated a prevalence rate of 19.3% for gastroesophageal reflux disease, defined as heartburn and/or acid regurgitation at least once a week or more frequent. We found a significant association of gastroesophageal reflux disease with age, obesity, lying down within two hours after meals, and being under stress within the last one year, but not with smoking. Comorbid diseases associated with gastroesophageal reflux disease presence included recurrent pharyngitis, chronic cough, asthma, diabetes mellitus, hypertension, and chronic obstructive pulmonary disease, but not coronary heart disease. 50.8% of our subjects had visited a physician for gastroesophageal reflux disease symptoms. The most common drug they used was proton pump inhibitors.
The prevalence of gastroesophageal reflux disease in a city of the Middle Anatolian region of Turkey was similar to that in developed countries and also to the results of another study performed in the Western part of Turkey. Further studies are needed to elucidate the role of environmental factors in the development of gastroesophageal reflux disease.
背景/目的：土耳其关于胃食管反流病的流行病学数据匮乏。因此，我们旨在确定我们所在地区胃食管反流病的患病率，并将其与土耳其西部地区以及世界其他国家进行比较。
我们使用了一份先前经过验证的反流问卷，并将其应用于1345名按社会经济地位分层的随机样本中，这些受试者年龄超过20岁，居住在锡瓦斯市中心。问卷由参加公共卫生实习的医学生进行。
我们估计胃食管反流病的患病率为19.3%，定义为每周至少出现一次烧心和/或反酸或更频繁。我们发现胃食管反流病与年龄、肥胖、饭后两小时内躺下以及过去一年内处于压力状态存在显著关联，但与吸烟无关。与胃食管反流病存在相关的合并症包括复发性咽炎、慢性咳嗽、哮喘、糖尿病、高血压和慢性阻塞性肺疾病，但不包括冠心病。我们的受试者中有50.8%因胃食管反流病症状看过医生。他们使用的最常见药物是质子泵抑制剂。
土耳其安纳托利亚中部地区一个城市的胃食管反流病患病率与发达国家相似，也与在土耳其西部地区进行的另一项研究结果相似。需要进一步研究以阐明环境因素在胃食管反流病发展中的作用。
