Department of Nutrition, University of California, 95616, Davis, California.
Biol Trace Elem Res. 1985 Sep;8(2):123-36. doi: 10.1007/BF02917466.
The interaction between dietary copper and zinc as determined by tissue concentrations of trace elements was investigated in male Sprague-Dawley rats. Animals were fed diets in a factorial design with two levels of copper (0.5, 5 μg/g) and five levels of zinc (1, 4.5, 10, 100, 1000 μg/g) for 42 d. In rats fed the low copper diet, as dietary zinc concentration increased, the level of copper decreased in brain, testis, spleen, heart, liver, and intestine. There was no significant effect of dietary copper on tissue zinc levels. In the zinc-deficient groups, the level of iron was higher in most tissues than in tissues from controls (5 μg Cu, 100 μg Zn/g diet). In the copper-deficient groups, iron concentration was higher than control values only in the liver. These data show that dietary zinc affected tissue copper levels primarily when dietary copper was deficient, that dietary copper had no effect on tissue zinc, and that both zinc deficiency and copper deficiency affected tissue iron levels.
本研究通过微量元素组织浓度来确定膳食铜锌之间的相互作用，选用雄性 Sprague-Dawley 大鼠作为研究对象。动物以双因子设计的方式进行饲养，实验共设置两个铜水平（0.5、5 μg/g）和五个锌水平（1、4.5、10、100、1000 μg/g），为期 42 天。在喂食低铜饮食的大鼠中，随着膳食锌浓度的增加，大脑、睾丸、脾脏、心脏、肝脏和肠道中的铜含量降低。膳食铜对组织锌水平没有显著影响。在缺锌组中，大多数组织中的铁含量高于对照组（5 μg Cu、100 μg Zn/g 饮食）。在铜缺乏组中，只有肝脏中的铁浓度高于对照值。这些数据表明，当膳食铜缺乏时，膳食锌主要影响组织铜水平，膳食铜对组织锌没有影响，锌缺乏和铜缺乏均会影响组织铁水平。
Zotero 插件