Department of Applied Science, Brookhaven National Laboratory, 11973, Upton, NY.
Biol Trace Elem Res. 1987 Apr;12(1):3-16. doi: 10.1007/BF02796662.
Many biomedical experiments require the qualitative and quantitative localization of trace elements with high sensitivity and good spatial resolution. The feasibility of measuring the chemical form of the elements, the time course of trace element metabolism, and conducting experiments in living biological systems are also important requirements for biological trace element research. Nuclear analytical techniques that employ ion or photon beams have grown in importance in the past decade and have led to several new experimental approaches. Some of the important features of these methods are reviewed here along with their role in trace element research. Examples of their use are given to illustrate potential for new research directions. It is emphasized that the effective application of these methods necessitates a closely integrated multidisciplinary scientific team.
许多生物医学实验需要具有高灵敏度和良好空间分辨率的痕量元素的定性和定量定位。测量元素的化学形态、痕量元素代谢的时间过程以及在活体生物系统中进行实验的可行性也是生物痕量元素研究的重要要求。过去十年中，利用离子或光子束的核分析技术的重要性日益增加，并带来了几种新的实验方法。本文回顾了这些方法的一些重要特点及其在痕量元素研究中的作用。并给出了它们的应用实例，以说明新的研究方向的潜力。本文强调，这些方法的有效应用需要一个紧密结合的多学科科学团队。
