一种罕见血型抗原，奥拉（奥尔代德），与弱Rh抗原相关。

A rare blood group antigen, Ola (Oldeide), associated with weak Rh antigens.

作者信息

Kornstad L

出版信息

Vox Sang. 1986;50(4):235-9. doi: 10.1111/j.1423-0410.1986.tb04888.x.

DOI:10.1111/j.1423-0410.1986.tb04888.x

Abstract

A 'new', rare blood group antigen, Ola (Oldeide), is described. Only one Ol(a+) person was found among the 7,151 blood donors tested. Examination of the family of the proposita revealed 10 additional Ol(a+) persons. The study indicated that Ola is inherited as a Mendelian dominant character and segregates independently of the ABO, MNSs, P, Rh and Kidd blood group systems, of the ABH secretor genes, and of sex. Ol(a+) family members had depressed Rh antigens, while the Ol(a-) members had Rh antigens of normal strength. The depression was particularly pronounced for the C and E antigens, less marked for the D antigen. Individual antisera differed in their ability to demonstrate the presence of the antigens. Depression of the c and e antigens could not be demonstrated conclusively with the antisera available.

摘要

一种“新的”、罕见的血型抗原Ola（奥尔德德）被描述。在检测的7151名献血者中仅发现1名Ol(a+)个体。对先证者家族的检查发现另外还有10名Ol(a+)个体。该研究表明，Ola作为孟德尔显性性状遗传，并且与ABO、MNSs、P、Rh和基德血型系统、ABH分泌型基因以及性别独立分离。Ol(a+)家族成员的Rh抗原减弱，而Ol(a-)成员的Rh抗原强度正常。C和E抗原的减弱尤为明显，D抗原的减弱则不太明显。不同的个体抗血清在证明抗原存在的能力上有所不同。现有的抗血清无法确凿地证明c和e抗原的减弱。