Mutreja Deepti, Kotru Mrinalini, Sazawal Sudha, Ranjan Ravi, Sharma Amit, Acharya Subrat Kumar, Saxena Renu
Department of Hematology, All India Institute of Medical Sciences, New Delhi, India.
Department of Gastroenterology, All India Institute of Medical Sciences, New Delhi, India.
Clin Appl Thromb Hemost. 2015 Sep;21(6):521-6. doi: 10.1177/1076029613511520. Epub 2013 Nov 19.
The purpose of this study was to characterize differences in the prevalence of hereditary and acquired thrombophilia in patients with splanchnic vein thrombosis (SVT). A total of 88 consecutive patients with SVT, including Budd Chiari Syndrome (n = 47) and portal extrahepatic portal vein obstruction (n = 41), underwent comprehensive thrombophilia testing, including testing for heritable and acquired causes. In 33 (37.5%) patients, etiology could be explained by at least 1 of the heritable etiologic factors, and 31 (35.2%) patients could be explained by at least 1 of the acquired causes studied. The combination of multiple concurrent factors was present in 9 (11.4%) patients. Among the heritable causes, the risk of SVT was found increased in the presence of thrombophilia resulting from the deficiencies of the naturally occurring anticoagulant proteins, and the acquired thrombogenic factors were significantly associated with causation of thrombosis in adult patients with SVT.
本研究的目的是描述内脏静脉血栓形成（SVT）患者遗传性和获得性血栓形成倾向患病率的差异。共有88例连续的SVT患者，包括布加综合征（n = 47）和肝外门静脉阻塞（n = 41），接受了全面的血栓形成倾向检测，包括对遗传性和获得性病因的检测。在33例（37.5%）患者中，病因可由至少1种遗传性病因因素解释，31例（35.2%）患者可由至少1种所研究的获得性病因解释。9例（11.4%）患者存在多种并发因素。在遗传性病因中，发现存在由天然抗凝蛋白缺乏导致的血栓形成倾向时，SVT风险增加，并且获得性血栓形成因素与成年SVT患者的血栓形成病因显著相关。
