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Ethnic-specific in vitro-in vivo extrapolation and physiologically based pharmacokinetic approaches to predict cytochrome P450-mediated pharmacokinetics in the Chinese population: opportunities and challenges.

作者信息

Li Guo-Fu, Yu Guo, Liu Hong-Xia, Zheng Qing-Shan

机构信息

Center for Drug Clinical Research, Shanghai University of Chinese Medicine, No. 1200 Cailun Road, Shanghai, 201203, China.

出版信息

Clin Pharmacokinet. 2014 Feb;53(2):197-202. doi: 10.1007/s40262-013-0119-9.

DOI:10.1007/s40262-013-0119-9
PMID:24255013
Abstract
摘要

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Ethnic-specific in vitro-in vivo extrapolation and physiologically based pharmacokinetic approaches to predict cytochrome P450-mediated pharmacokinetics in the Chinese population: opportunities and challenges.基于种族特异性的体外-体内外推法和生理药代动力学方法预测中国人群中细胞色素P450介导的药代动力学：机遇与挑战
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Differences in cytochrome p450-mediated pharmacokinetics between chinese and caucasian populations predicted by mechanistic physiologically based pharmacokinetic modelling.基于机制的生理药代动力学模型预测中国人与高加索人群细胞色素 P450 介导的药代动力学差异。
Clin Pharmacokinet. 2013 Dec;52(12):1085-100. doi: 10.1007/s40262-013-0089-y.
2
Prediction of warfarin maintenance dose in Han Chinese patients using a mechanistic model based on genetic and non-genetic factors.基于遗传和非遗传因素的机制模型预测汉族华法林维持剂量。
Clin Pharmacokinet. 2013 Jul;52(7):567-81. doi: 10.1007/s40262-013-0054-9.
3
CYP2C8 polymorphism frequencies among Han, Uighur, Hui, and Mongolian Chinese populations.
种族特异性肝微粒体标化因子、肝重和细胞色素 P450（CYP）1A2 含量对青年和老年中国成年人 CYP1A2 介导的药代动力学的生理相关预测的影响。
Clin Pharmacokinet. 2019 Jul;58(7):927-941. doi: 10.1007/s40262-019-00737-5.
4
Interethnic scaling of fraction unbound of a drug in plasma and volume of distribution: an analysis of extrapolation from Caucasians to Chinese.药物血浆中游离分数和分布容积的种族间标度：从高加索人外推至中国人的分析。
Eur J Clin Pharmacol. 2019 Apr;75(4):543-551. doi: 10.1007/s00228-018-02610-z. Epub 2018 Dec 19.
5
Population Pharmacokinetics, Safety and Tolerability of Extended-Release Bupropion and Its Three Metabolites in Chinese Healthy Volunteers.安非他酮缓释片及其三种代谢产物在中国健康志愿者中的群体药代动力学、安全性和耐受性
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Content and activity of human liver microsomal protein and prediction of individual hepatic clearance in vivo.人肝微粒体蛋白的含量与活性及体内个体肝清除率的预测
Sci Rep. 2015 Dec 4;5:17671. doi: 10.1038/srep17671.
中国汉族、维吾尔族、回族和蒙古族人群中CYP2C8基因多态性频率。
Genet Test Mol Biomarkers. 2013 Feb;17(2):104-8. doi: 10.1089/gtmb.2012.0256.
4
An improved model to predict physiologically based model parameters and their inter-individual variability from anthropometry.从人体测量学角度预测生理相关模型参数及其个体间变异性的改进模型。
Crit Rev Toxicol. 2012 Oct;42(9):751-67. doi: 10.3109/10408444.2012.709225. Epub 2012 Sep 7.
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The role of physiologically based pharmacokinetic modeling in regulatory review.生理药代动力学建模在监管审查中的作用。
Clin Pharmacol Ther. 2012 Mar;91(3):542-9. doi: 10.1038/clpt.2011.320. Epub 2012 Feb 8.
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Physiologically based pharmacokinetic (PBPK) modelling tools: how to fit with our needs?基于生理学的药代动力学（PBPK）建模工具：如何满足我们的需求？
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Allele and genotype frequencies of CYP3A4, CYP2C19, and CYP2D6 in Han, Uighur, Hui, and Mongolian Chinese populations.汉族、维吾尔族、回族和蒙古族人群中CYP3A4、CYP2C19和CYP2D6的等位基因及基因型频率。
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Pharmacokinetics of losartan and its active carboxylic acid metabolite E-3174 in five ethnic populations of China.在中国五个不同种族人群中洛沙坦及其活性羧酸代谢物 E-3174 的药代动力学研究。
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