Goel Renu, Raju Rajesh, Maharudraiah Jagadeesha, Sameer Kumar Ghantasala S, Ghosh Krishna, Kumar Amit, Lakshmi T Pragna, Sharma Jyoti, Sharma Rakesh, Balakrishnan Lavanya, Pan Archana, Kandasamy Kumaran, Christopher Rita, Krishna V, Mohan S Sujatha, Harsha H C, Mathur Premendu P, Pandey Akhilesh, Keshava Prasad T S
Institute of Bioinformatics, International Tech Park, Bangalore-560 066, India ; Department of Biotechnology, Kuvempu University, Shankaraghatta-577 451, India.
J Proteomics Bioinform. 2011 Oct 29;4. doi: 10.4172/jpb.1000195.
Human thyroid stimulating hormone (TSH) is a glycoprotein secreted by the anterior part of the pituitary gland. TSH plays an important physiological role in the regulation of hypothalamic-pituitary-thyroid axis by modulating the release of the thyroid hormones from the thyroid gland. It induces iodine uptake by the thyroid, promotes thyroid epithelial differentiation and growth, and protects thyroid cells from apoptosis. Impairment of TSH signal transduction pathway leads to thyroid disorders such as goitre, hypothyroidism and hyperthyroidism, which can have complex clinical manifestations. TSH signaling is largely effected through two separate pathways, the adenylate cyclase and the phospholipase C pathways. In spite of its biomedical importance, a concise signaling map of TSH pathway is not available in the public domain. Therefore, we have generated a detailed signaling map of TSH pathway by systematically cataloging the molecular reactions induced by TSH including protein-protein interactions, post-translational modifications, protein translocation events and activation/inhibition reactions. We have cataloged 40 molecular association events, 42 enzyme-substrate reactions and 16 protein translocation events in TSH signaling pathway resource. Additionally, we have documented 208 genes, which are differentially regulated by TSH. We have provided the details of TSH pathway through NetPath (http://www.netpath.org), which is a publicly available resource for human signaling pathways developed by our group. We have also depicted the map of TSH signaling using NetSlim criteria (http://www.netpath.org/netslim/) and provided pathway maps in Wikipathways (http://www.wikipathways.org/). We anticipate that the availability of TSH pathway as a community resource will enhance further biomedical investigations into the function and effects of this important hormone.
人促甲状腺激素（TSH）是一种由垂体前叶分泌的糖蛋白。TSH通过调节甲状腺激素从甲状腺的释放，在下丘脑 - 垂体 - 甲状腺轴的调节中发挥重要的生理作用。它诱导甲状腺摄取碘，促进甲状腺上皮细胞分化和生长，并保护甲状腺细胞免于凋亡。TSH信号转导通路的损伤会导致甲状腺疾病，如甲状腺肿、甲状腺功能减退和甲状腺功能亢进，这些疾病可能有复杂的临床表现。TSH信号传导主要通过两条独立的途径实现，即腺苷酸环化酶途径和磷脂酶C途径。尽管其在生物医学方面具有重要意义，但公共领域中尚无TSH通路的简明信号图谱。因此，我们通过系统地编目TSH诱导的分子反应，包括蛋白质 - 蛋白质相互作用、翻译后修饰、蛋白质转位事件和激活/抑制反应，生成了TSH通路的详细信号图谱。我们在TSH信号通路资源中编目了40个分子关联事件、42个酶 - 底物反应和16个蛋白质转位事件。此外，我们记录了208个受TSH差异调节的基因。我们通过NetPath（http://www.netpath.org）提供了TSH通路的详细信息，NetPath是我们团队开发的用于人类信号通路的公开可用资源。我们还使用NetSlim标准（http://www.netpath.org/netslim/）描绘了TSH信号图谱，并在Wikipathways（http://www.wikipathways.org/）中提供了通路图谱。我们预计，TSH通路作为一种社区资源的可用性将加强对这种重要激素的功能和作用的进一步生物医学研究。
