Department of Pharmaceutical Sciences, School of Pharmacy, University of California, Irvine, CA 92697, USA.
Department of Occupational and Environmental Health, University of California, Irvine, CA 92697, USA.
Int J Mol Sci. 2023 May 5;24(9):8263. doi: 10.3390/ijms24098263.
Hormones are indispensable for bone development, growth, and maintenance. While many of the genes associated with osteogenesis are well established, it is the recent findings in endocrinology that are advancing the fields of bone biology and toxicology. Endocrine-disrupting chemicals (EDCs) are defined as chemicals that interfere with the function of the endocrine system. Here, we report recent discoveries describing key hormone pathways involved in osteogenesis and the EDCs that alter these pathways. EDCs can lead to bone morphological changes via altering hormone receptors, signaling pathways, and gene expression. The objective of this review is to highlight the recent discoveries of the harmful effects of environmental toxicants on bone formation and the pathways impacted. Understanding the mechanisms of how EDCs interfere with bone formation contributes to providing a comprehensive toxicological profile of a chemical.
激素对于骨骼的发育、生长和维持是不可或缺的。虽然许多与成骨相关的基因已经得到很好的确定，但正是内分泌学的最新发现推动了骨生物学和毒理学领域的发展。内分泌干扰物 (EDC) 被定义为干扰内分泌系统功能的化学物质。在这里，我们报告了最近的发现，描述了参与成骨的关键激素途径以及改变这些途径的 EDC。EDC 可通过改变激素受体、信号通路和基因表达导致骨骼形态发生变化。本综述的目的是强调环境毒物对骨形成的有害影响及其受影响的途径的最新发现。了解 EDC 干扰骨形成的机制有助于提供化学物质的全面毒理学概况。
