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Obsessive compulsive disorder networks: positron emission tomography and neuropsychology provide new insights.强迫症网络:正电子发射断层扫描和神经心理学提供新的见解。
PLoS One. 2013;8(1):e53241. doi: 10.1371/journal.pone.0053241. Epub 2013 Jan 11.
2
Obsessive-compulsive symptoms in patients with schizophrenia: a naturalistic cross-sectional study comparing treatment with clozapine, olanzapine, risperidone, and no antipsychotics in 543 patients.精神分裂症患者的强迫症状:一项自然横断面研究,比较了 543 例患者使用氯氮平、奥氮平、利培酮和无抗精神病药物治疗的效果。
J Clin Psychiatry. 2012 Nov;73(11):1395-402. doi: 10.4088/JCP.11m07164.
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Clozapine-induced obsessive-compulsive symptoms in schizophrenia: a critical review.氯氮平致精神分裂症强迫症状:批判性评价。
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Age-of-onset of schizophrenic and obsessive-compulsive symptoms in patients with schizo-obsessive disorder.精神分裂-强迫障碍患者中精神分裂症和强迫症症状出现的年龄。
Psychiatry Res. 2012 May 15;197(1-2):19-22. doi: 10.1016/j.psychres.2012.02.024. Epub 2012 Mar 20.
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Obsessive-compulsive symptoms in schizophrenia: implications for future psychiatric classifications.精神分裂症中的强迫症状:对未来精神科分类的影响。
Compr Psychiatry. 2012 Jul;53(5):480-3. doi: 10.1016/j.comppsych.2011.08.009. Epub 2011 Oct 27.
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The characterization of beliefs in obsessive-compulsive disorder.强迫症信念的特征。
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Arch Gen Psychiatry. 2009 Nov;66(11):1189-200. doi: 10.1001/archgenpsychiatry.2009.152.
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Relationships between obsessive-compulsive symptomatology and severity of psychosis in schizophrenia: a systematic review and meta-analysis.精神分裂症中强迫症状与精神病严重程度之间的关系:一项系统评价和荟萃分析。
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精神分裂症中强迫症状与妄想的鉴别诊断:一种现象学方法。

Differential diagnosis of obsessive-compulsive symptoms from delusions in schizophrenia: A phenomenological approach.

机构信息

Panagiotis Oulis, George Konstantakopoulos, First Department of Psychiatry, Athens University Medical School, Eginition Hospital, 11528 Athens, Greece.

出版信息

World J Psychiatry. 2013 Sep 22;3(3):50-6. doi: 10.5498/wjp.v3.i3.50.

DOI:10.5498/wjp.v3.i3.50
PMID:24255875
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3832861/
Abstract

Several studies suggest increased prevalence-rates of obsessive-compulsive symptoms (OCS) and even of obsessive-compulsive disorder (OCD) in patients with schizophrenic disorders. Moreover, it has been recently proposed the existence of a distinct diagnostic sub-group of schizo-obsessive disorder. However, the further investigation of the OCS or OCD-schizophrenia diagnostic comorbidity presupposes the accurate clinical differential diagnosis of obsessions and compulsions from delusions and repetitive delusional behaviours, respectively. In turn, this could be facilitated by a careful comparative examination of the phenomenological features of typical obsessions/compulsions and delusions/repetitive delusional behaviours, respectively. This was precisely the primary aim of the present investigation. Our examination included seven features of obsessions/delusions (source of origin and sense of ownership of the thought, conviction, consistency with one's belief-system, awareness of its inaccuracy, awareness of its symptomatic nature, resistance, and emotional impact) and five features of repetitive behaviours (aim of repetitive behaviours, awareness of their inappropriateness, awareness of their symptomatic nature, and their immediate effect on underlying thought, and their emotional impact). Several of these clinical features, if properly and empathically investigated, can help discriminate obsessions and compulsive rituals from delusions and delusional repetitive behaviours, respectively, in patients with schizophrenic disorders. We comment on the results of our examination as well as on those of another recent similar investigation. Moreover, we also address several still controversial issues, such as the nature of insight, the diagnostic status of poor insight in OCD, the conceptualization and differential diagnosis of compulsions from other categories of repetitive behaviours, as well as the diagnostic weight assigned to compulsions in contemporary psychiatric diagnostic systems. We stress the importance of the feature of mental reflexivity for understanding the nature of insight and the ambiguous diagnostic status of poor insight in OCD which may be either a marker of the chronicity of obsessions, or a marker of their delusionality. Furthermore, we criticize two major shortcomings of contemporary psychiatric diagnostic systems (DSM-IV, DSM-V, ICD-10) in their criteria or guidelines for the diagnosis of OCD or OCS: first, the diagnostic parity between obsessions and compulsions and, second, the inadequate conceptualization of compulsions. We argue that these shortcomings might artificially inflate the clinical prevalence of OC symptoms in the course of schizophrenic disorders. Still, contrary to a recent proposal, we do not exclude on purely a priori grounds the possibility of a concurrence of genuine obsessions along with delusions in patients with schizophrenia.

摘要

几项研究表明,精神分裂症患者中强迫症状(OCS)甚至强迫症(OCD)的患病率有所增加。此外,最近有人提出存在一种独特的精神分裂症强迫性诊断亚组。然而,对 OCS 或 OCD-精神分裂症诊断共病的进一步研究需要准确地对妄想和重复妄想行为中的强迫观念和强迫行为进行临床鉴别诊断。反过来,这可以通过仔细比较典型的强迫观念/强迫行为和妄想/重复妄想行为的现象学特征来促进。这正是本研究的主要目的。我们的检查包括强迫观念/妄想的七个特征(思维的来源和所有权,信念,与一个人的信仰体系的一致性,对其不准确性的认识,对其症状性质的认识,抗拒,和情绪影响)和重复行为的五个特征(重复行为的目的,对其不适当性的认识,对其症状性质的认识,以及对潜在思维的即时影响,以及对其情绪的影响)。如果对这些临床特征进行适当和同情的调查,就可以帮助区分精神分裂症患者的强迫观念和强迫仪式与妄想和重复妄想行为。我们对检查结果以及另一项最近的类似研究的结果进行了评论。此外,我们还讨论了几个仍有争议的问题,例如洞察力的本质,在 OCD 中洞察力差的诊断地位,对强迫行为的概念化和鉴别诊断,以及在当代精神科诊断系统中赋予强迫行为的诊断权重。我们强调了心理反思性特征对理解洞察力的本质以及 OCD 中洞察力差的模糊诊断地位的重要性,这可能是强迫观念的慢性的标志,也可能是其妄想性的标志。此外,我们批评了当代精神科诊断系统(DSM-IV、DSM-V、ICD-10)在 OCD 或 OCS 诊断标准或指南中的两个主要缺陷:第一,强迫观念和强迫行为之间的诊断等同性,第二,对强迫行为的概念化不足。我们认为,这些缺陷可能会人为地增加精神分裂症过程中 OC 症状的临床患病率。尽管如此,与最近的一项提议相反,我们并没有纯粹从先验的角度排除在精神分裂症患者中存在真正的强迫观念和妄想的可能性。