Babos Levente, Járai Zoltán, Nemcsik János
Levente Babos, János Nemcsik, Department of Family Medicine, Semmelweis University, 1125 Budapest, Hungary.
World J Nephrol. 2013 Aug 6;2(3):77-83. doi: 10.5527/wjn.v2.i3.77.
Cardiovascular diseases are the major causes of mortality in patients with chronic kidney disease (CKD). The complex process of accelerated athero- and arteriosclerosis in CKD is associated with this phenomenon, where endothelial dysfunction (ED) is one of the initial steps. Hence, the early diagnosis of ED can potentially lead to early interventions which could result in a better outcome for these patients. Several methodologies have been developed for the diagnosis of ED. Laser Doppler flowmetry (LDF) enables us to study the microcirculation continuously in a non-invasive manner. In our review we would like to focus on different tests developed for LDF, like postocclusive reactive hyperaemia, local heating, iontophoresis, microdialysis or analysis of flowmotion. We would also like to summarize the available data in CKD with these methodologies to enlighten their perspectives in the clinical use on this patient population.
心血管疾病是慢性肾脏病（CKD）患者死亡的主要原因。CKD中加速动脉粥样硬化和动脉硬化的复杂过程与这一现象相关，其中内皮功能障碍（ED）是初始步骤之一。因此，ED的早期诊断可能会带来早期干预，从而为这些患者带来更好的结果。已经开发了几种用于诊断ED的方法。激光多普勒血流仪（LDF）使我们能够以非侵入性方式持续研究微循环。在我们的综述中，我们将重点关注为LDF开发的不同测试，如闭塞后反应性充血、局部加热、离子电渗疗法、微透析或血流运动分析。我们还将总结使用这些方法在CKD中获得的现有数据，以阐明它们在该患者群体临床应用中的前景。
