*Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, U.K.
Biochem Soc Trans. 2013 Dec;41(6):1726-30. doi: 10.1042/BST20130200.
Centromere proteins CENP-S and CENP-X are members of the constitutive centromere-associated network, which is a conserved group of proteins that are needed for the assembly and function of kinetochores at centromeres. Intriguingly CENP-S and CENP-X have alter egos going by the names of MHF1 (FANCM-associated histone-fold protein 1) and MHF2 respectively. In this guise they function with a DNA translocase called FANCM (Fanconi's anemia complementation group M) to promote DNA repair and homologous recombination. In the present review we discuss current knowledge of the biological roles of CENP-S and CENP-X and how their dual existence may be a common feature of CCAN (constitutive centromere-associated network) proteins.
着丝粒蛋白 CENP-S 和 CENP-X 是组成性着丝粒相关网络的成员，该网络是一个保守的蛋白质组，对于组装和发挥着丝粒处动粒的功能是必需的。有趣的是，CENP-S 和 CENP-X 有别名，分别称为 MHF1（FANCM 相关组蛋白折叠蛋白 1）和 MHF2。在这种伪装下，它们与一种称为 FANCM（范可尼贫血互补组 M）的 DNA 转位酶一起发挥作用，以促进 DNA 修复和同源重组。在本综述中，我们讨论了 CENP-S 和 CENP-X 的生物学作用的现有知识，以及它们的双重存在如何可能是 CCAN（组成性着丝粒相关网络）蛋白的共同特征。
