State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences , Lanzhou 730000, People's Republic of China.
J Am Chem Soc. 2013 Dec 11;135(49):18327-30. doi: 10.1021/ja410611b. Epub 2013 Nov 23.
A new strategy was developed for intercepting the palladium-alkyl species generated in Heck reaction via nucleophilic addition prior to the step of migratory insertion, which leads to a new palladium-catalyzed difunctionalization of enol ethers with aminals and alcohols to afford amino acetals. Mechanistic studies suggested that the cationic cyclometalated Pd(II) complex generated by the oxidative addition of aminal to a Pd(0) species was crucial for this unusual transformation.
开发了一种新策略，用于在 Heck 反应中钯-烷基物种发生迁移插入步骤之前通过亲核加成来拦截它们，从而导致烯醚与亚胺和醇的新型钯催化双官能化反应，生成氨基缩醛。机理研究表明，亚胺的氧化加成到 Pd(0)物种生成的阳离子环金属化 Pd(II)配合物对于这种不寻常的转化至关重要。
