Strickler J G, Michie S A, Warnke R A, Dorfman R F
Am J Surg Pathol. 1986 Jul;10(7):470-7. doi: 10.1097/00000478-198607000-00004.
The histologic and immunologic features of an unusual morphologic expression of nodular sclerosing Hodgkin's disease, which ahs been termed the "syncytial variant," are described. In biopsy material from 18 cases, numerous Reed-Sternberg cell variants were observed in sheets and cohesive clusters, and at least focal evidence of nodular sclerosis was present in each case. The granulocyte antibody anti-Leu M1 reacted with antigenic determinants in Reed-Sternberg cells and atypical variants thereof in 13 of the 18 cases; the lack of staining with antibodies reactive with the leukocyte common (T200) antigen (PD7/26), keratin (AE1), and S100 protein (polyclonal anti-S100) was helpful in excluding non-Hodgkin's lymphoma, carcinoma, and melanoma, respectively. This unusual form of nodular sclerosing Hodgkin's disease is important to recognize, since it may simulate metastatic neoplasms, thymoma, and non-Hodgkin's lymphoma.
本文描述了结节硬化型霍奇金病一种不同寻常形态学表现（被称为“合胞体变体”）的组织学和免疫学特征。在18例活检材料中，可见大量里德-斯腾伯格细胞变体呈片状及紧密聚集，且每例均至少有局灶性结节硬化证据。粒细胞抗体抗Leu M1在18例中的13例里德-斯腾伯格细胞及其非典型变体中与抗原决定簇发生反应；缺乏与白细胞共同抗原（T200）抗原（PD7/26）、角蛋白（AE1）和S100蛋白（多克隆抗S100）反应的抗体染色，分别有助于排除非霍奇金淋巴瘤、癌和黑色素瘤。这种不寻常形式的结节硬化型霍奇金病的识别很重要，因为它可能类似转移性肿瘤、胸腺瘤和非霍奇金淋巴瘤。
