a Department of Pediatric Hematology-Oncology and Stem Cell Transplantation , Ghent University Hospital, 3K12D , De Pintelaan 185, 9000 Ghent , Belgium.
Vet Q. 2013 Dec;33(4):202-6. doi: 10.1080/01652176.2013.866297. Epub 2013 Dec 16.
Pluripotent stem cells are defined by their unlimited self-renewal capacities and potential to differentiate into any cell lineage. Many crucial determinants for the induction and maintenance of this pluripotent state have been identified. Long non-coding RNAs have recently emerged as key regulators of pluripotent stem cells and have enhanced our understanding of their potential functions in tissue regeneration. This review provides an overview of recent important insights into the roles of long non-coding RNAs as regulators and markers of pluripotency.
多能干细胞的定义是其具有无限自我更新能力和分化为任何细胞谱系的潜力。已经确定了许多诱导和维持这种多能状态的关键决定因素。长非编码 RNA 最近成为多能干细胞的关键调节因子，并增强了我们对其在组织再生中的潜在功能的理解。本文综述了长非编码 RNA 作为多能性调控因子和标志物的最新重要研究进展。
