肺泡巨噬细胞和肺T细胞衍生介质在结节病中的作用。

Role of alveolar macrophage- and lung T cell-derived mediators in pulmonary sarcoidosis.

作者信息

Hunninghake G W

出版信息

Ann N Y Acad Sci. 1986;465:82-90. doi: 10.1111/j.1749-6632.1986.tb18483.x.

DOI:10.1111/j.1749-6632.1986.tb18483.x

Abstract

The process of granuloma formation in the lung is mediated by an intimate interaction between macrophages and T cells, and this interaction provides the appropriate environment for granuloma formation and the development of fibrosis. Much of this process of granuloma formation and fibrosis appears to be triggered by the release of immune mediators by alveolar macrophages and lung T cells.

摘要

肺部肉芽肿形成过程由巨噬细胞和T细胞之间的密切相互作用介导，这种相互作用为肉芽肿形成和纤维化发展提供了适宜环境。肉芽肿形成和纤维化的这一过程大多似乎是由肺泡巨噬细胞和肺T细胞释放免疫介质所触发。