Hunninghake G W, Gadek J E, Young R C, Kawanami O, Ferrans V J, Crystal R G
N Engl J Med. 1980 Mar 13;302(11):594-8. doi: 10.1056/NEJM198003133021102.
Pulmonary granulomata of sarcoidosis are composed primarily of mononuclear phagocytic cells that are probably derived from blood monocytes. To evaluate the concept that recruitment of blood monocytes to the sarcoid lung is mediated by chemoattractants produced by immune effector cells within the lung, we obtained mononuclear cells from lung and blood of six patients with active pulmonary sarcoidosis, six normal subjects, and six patients with active idiopathic pulmonary fibrosis and studied their ability to secrete a chemotactic factor for monocytes. Lung T lymphocytes from all sarcoidosis patients, but not from normal subjects or patients with idiopathic pulmonary fibrosis, spontaneously secreted such a mediator. Lung T lymphocytes from patients with sarcoidosis secreted more monocyte chemotactic factor than did blood T lymphocytes from the same patients. The accumulation of monocytes in the lung in patients with pulmonary sarcoidosis may be mediated by local production of monocyte chemotactic factor by lung T lymphocytes.
结节病的肺肉芽肿主要由可能源自血液单核细胞的单核吞噬细胞组成。为了评估血液单核细胞向结节病肺组织募集是由肺内免疫效应细胞产生的趋化因子介导这一概念，我们从6例活动性肺结节病患者、6例正常受试者以及6例活动性特发性肺纤维化患者的肺组织和血液中获取单核细胞，并研究了它们分泌单核细胞趋化因子的能力。所有结节病患者的肺T淋巴细胞，而非正常受试者或特发性肺纤维化患者的肺T淋巴细胞，可自发分泌这样一种介质。结节病患者的肺T淋巴细胞比同一患者的血液T淋巴细胞分泌更多的单核细胞趋化因子。肺结节病患者肺内单核细胞的积聚可能是由肺T淋巴细胞局部产生单核细胞趋化因子所介导的。
