Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan.
Int J Mol Sci. 2013 Nov 19;14(11):22817-25. doi: 10.3390/ijms141122817.
Plasma YKL-40 level has been reported as playing a significant role in community-acquired pneumonia (CAP). However, the correlation between plasma level of YKL-40 and the severity of CAP has not been reported. This study identifies the relationship between plasma level changes of the YKL-40 gene in adult patients hospitalized with CAP. The ELISA was used to measure the plasma YKL-40 level from 61 adult CAP patients before and after antibiotic treatment and from 60 healthy controls. The plasma YKL-40 levels were significantly increased in patients with CAP compared to normal controls. Moreover, the plasma concentration of YKL-40 correlated with the severity of CAP based on the pneumonia severity index (PSI) score (r = 0.630, p < 0.001), the CURB-65 (confusion, uremia, respiratory rate, BP, age 65 years) score (r = 0.640, p < 0.001), the Acute Physiology And Chronic Health Evaluation II (APACHE II) score (r = 0.539, p < 0.001) and length of hospital stay (r = 0.321, p = 0.011), respectively. In conclusion, plasma YKL-40 may play a role in the diagnosis and clinical assessment of CAP severity, which could potentially guide the development of treatment strategies.
已有研究报道，血清 YKL-40 水平在社区获得性肺炎（CAP）中发挥着重要作用。然而，血清 YKL-40 水平与 CAP 严重程度之间的相关性尚未见报道。本研究旨在探讨成人 CAP 患者的 YKL-40 基因在血浆中的变化与疾病严重程度的关系。采用酶联免疫吸附法（ELISA）检测 61 例 CAP 患者及 60 例健康对照者的血浆 YKL-40 水平，比较 CAP 患者治疗前后及健康对照组之间的 YKL-40 水平。结果发现，与健康对照组相比，CAP 患者的血浆 YKL-40 水平明显升高。此外，YKL-40 浓度与肺炎严重指数（PSI）评分（r = 0.630，p < 0.001）、CURB-65（意识障碍、血尿素氮、呼吸频率、血压、年龄≥65 岁）评分（r = 0.640，p < 0.001）、急性生理学与慢性健康状况评分系统 II（APACHE II）评分（r = 0.539，p < 0.001）及住院时间（r = 0.321，p = 0.011）呈正相关。结论：血清 YKL-40 可能在 CAP 的诊断和临床评估中发挥作用，有望为 CAP 的治疗策略提供指导。
